{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:26:17Z","timestamp":1777926377947,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>\n                    The benefit of induced hyperventilation for intracranial pressure (ICP) control after severe traumatic brain injury (TBI) is controversial. In this study, we investigated the impact of early and sustained hyperventilation on compliances of the cerebral arteries and of the cerebrospinal (CSF) compartment during mild hyperventilation in severe TBI patients. We included 27 severe TBI patients (mean 39.5\u2009\u00b1\u20093.4 years, 6 women) in whom an increase in ventilation (20% increase in respiratory minute volume) was performed during 50\u2009min as part of a standard clinical CO\n                    <jats:sub>2<\/jats:sub>\n                    reactivity test. Using a new mathematical model, cerebral arterial compliance (Ca) and CSF compartment compliance (Ci) were calculated based on the analysis of ICP, arterial blood pressure, and cerebral blood flow velocity waveforms. Hyperventilation initially induced a reduction in ICP (17.5\u2009\u00b1\u20096.6 vs. 13.9\u2009\u00b1\u20096.2 mmHg;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), which correlated with an increase in Ci (r\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.213;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.015). Concomitantly, the reduction in cerebral blood flow velocities (CBFV, 74.6\u2009\u00b1\u200927.0 vs. 62.9\u2009\u00b1\u200922.9\u2009cm\/sec;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) marginally correlated with the reduction in Ca (r\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.209;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.017). During sustained hyperventilation, ICP increased (13.9\u2009\u00b1\u20096.2 vs. 15.3\u2009\u00b1\u20096.4 mmHg;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), which correlated with a reduction in Ci (r\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.297;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.003), but no significant changes in Ca were found during that period. The early reduction in Ca persisted irrespective of the duration of hyperventilation, which may contribute to the lack of clinical benefit of hyperventilation after TBI. Further studies are needed to determine whether monitoring of arterial and CSF compartment compliances may detect and prevent an adverse ischemic event during hyperventilation.\n                  <\/jats:p>","DOI":"10.1089\/neu.2010.1377","type":"journal-article","created":{"date-parts":[[2011,1,4]],"date-time":"2011-01-04T15:37:24Z","timestamp":1294155444000},"page":"889-896","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Changes in Cerebral Compartmental Compliances during Mild Hypocapnia in Patients with Traumatic Brain Injury"],"prefix":"10.1177","volume":"28","author":[{"given":"Emmanuel","family":"Carrera","sequence":"first","affiliation":[{"name":"University of Cambridge","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luzius A.","family":"Steiner","sequence":"additional","affiliation":[{"name":"University Hospital","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Castellani","sequence":"additional","affiliation":[{"name":"University of Cambridge","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Smielewski","sequence":"additional","affiliation":[{"name":"University of Cambridge","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Zweifel","sequence":"additional","affiliation":[{"name":"University of Cambridge","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Haubrich","sequence":"additional","affiliation":[{"name":"University of Cambridge","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Pickard","sequence":"additional","affiliation":[{"name":"University of Cambridge","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David K.","family":"Menon","sequence":"additional","affiliation":[{"name":"University of Cambridge","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Czosnyka","sequence":"additional","affiliation":[{"name":"University of Cambridge","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,6,1]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.9.1148"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.91008.2008"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20427"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91046-J"},{"key":"e_1_3_4_6_1","first-page":"57","volume-title":"Cerebrospinal Fluid Pulse Pressure and Craniospinal Dynamics","author":"Avezaat C.J.","year":"1984","unstructured":"Avezaat C.J., , van Eijndhoven J.H. 1984. Cerebrospinal fluid pulse pressure. Cerebrospinal Fluid Pulse Pressure and Craniospinal Dynamics. Avezaat C.J., , van Eijndhoven J.H. Decor Davids: Amsterdam, 57\u201369."},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.42.8.687"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00327574"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2007.9982"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2009.0951"},{"key":"e_1_3_4_11_1","doi-asserted-by":"crossref","unstructured":"Carrera E. Kim D.J. Castellani G. Zweifel C. Smielewski P. Pickard J.D. Czosnyka M. 2010b. Effect of hyper and hypocapnia on cerebral arterial compliance in normal subjects. J. Neuroimaging(In press)","DOI":"10.1111\/j.1552-6569.2009.00439.x"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1981.tb01673.x"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000295802.89962.13"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1983.tb07198.x"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.3.692"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-196701000-00016"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101995"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/30\/7\/009"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.9.1713"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200001000-00003"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1975.43.5.0523"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1978.48.3.0332"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.12.1746"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199607000-00008"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.5.2.230"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199910000-00023"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.12.2244"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1964.206.1.25"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.04.005"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-211-32318-X_10"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-211-32318-X_4"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2463-6"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2008.2006010"},{"key":"e_1_3_4_34_1","first-page":"1929","article-title":"Changes in blood flow velocity and diameter of the middle cerebral artery during hyperventilation: assessment with MR and transcranial Doppler sonography","volume":"18","author":"Valdueza J.M.","year":"1997","unstructured":"Valdueza J.M., , Balzer J.O., , Villringer A., , Vogl T.J., , Kutter R., , Einhaupl K.M. 1997. Changes in blood flow velocity and diameter of the middle cerebral artery during hyperventilation: assessment with MR and transcranial Doppler sonography. Am. J. Neuroradiol., 18:1929\u20131934.","journal-title":"Am. J. Neuroradiol."},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0541k.x"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000188707"}],"container-title":["Journal of Neurotrauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/neu.2010.1377","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2010.1377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2010.1377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:12:56Z","timestamp":1777673576000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/neu.2010.1377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1089\/neu.2010.1377"],"URL":"https:\/\/doi.org\/10.1089\/neu.2010.1377","relation":{},"ISSN":["0897-7151","1557-9042"],"issn-type":[{"value":"0897-7151","type":"print"},{"value":"1557-9042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}