{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:27:29Z","timestamp":1777926449440,"version":"3.51.4"},"reference-count":83,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>\n                    There is growing evidence that neck pain is common in adolescence and is a risk factor for the development of chronic neck pain in adulthood. The cervical facet joint and its capsular ligament is a common source of pain in the neck in adults, but its role in adolescent pain remains unknown. The aim of this study was to define the biomechanics, behavioral sensitivity, and indicators of neuronal and glial activation in an adolescent model of mechanical facet joint injury. A bilateral C6\u2013C7 facet joint distraction was imposed in an adolescent rat and biomechanical metrics were measured during injury. Following injury, forepaw mechanical hyperalgesia was measured, and protein kinase C-epsilon (PKC\u025b) and metabotropic glutamate receptor-5 (mGluR5) expression in the dorsal root ganglion and markers of spinal glial activation were assessed. Joint distraction induced significant mechanical hyperalgesia during the 7 days post-injury (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Painful injury significantly increased PKC\u025b expression in small- and medium-diameter neurons compared to sham (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and na\u00efve tissue (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Similarly, mGluR5 expression was significantly elevated in small-diameter neurons after injury (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Spinal astrocytic activation after injury was also elevated over sham (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.035) and na\u00efve (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) levels; microglial activation was only greater than na\u00efve levels (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.006). Mean strains in the facet capsule during injury were 32.8\u2009\u00b1\u200912.9%, which were consistent with the strains associated with comparable degrees of hypersensitivity in the adult rat. These results suggest that adolescents may have a lower tissue tolerance to induce pain and associated nociceptive response than do adults.\n                  <\/jats:p>","DOI":"10.1089\/neu.2010.1460","type":"journal-article","created":{"date-parts":[[2010,10,6]],"date-time":"2010-10-06T11:09:01Z","timestamp":1286363341000},"page":"2261-2271","source":"Crossref","is-referenced-by-count":29,"title":["Metabotropic Glutamate Receptor-5 and Protein Kinase C-Epsilon Increase in Dorsal Root Ganglion Neurons and Spinal Glial Activation in an Adolescent Rat Model of Painful Neck Injury"],"prefix":"10.1177","volume":"27","author":[{"given":"Christine L.","family":"Weisshaar","sequence":"first","affiliation":[{"name":"University of Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Dong","sequence":"additional","affiliation":[{"name":"University of Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex S.","family":"Bowman","sequence":"additional","affiliation":[{"name":"University of South Carolina School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico M.","family":"Perez","sequence":"additional","affiliation":[{"name":"University of South Carolina School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin B.","family":"Guarino","sequence":"additional","affiliation":[{"name":"University of Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah M.","family":"Sweitzer","sequence":"additional","affiliation":[{"name":"University of South Carolina School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth A.","family":"Winkelstein","sequence":"additional","affiliation":[{"name":"University of Pennsylvania"},{"name":"University of Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,12,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.2.684"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.111534"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199207000-00003"},{"key":"e_1_3_3_5_1","first-page":"175","article-title":"Low back pain in schoolchildren. 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