{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:29:08Z","timestamp":1777926548224,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p>\n                    In adult mammals, restoration of function after peripheral nerve injury is often poor and effective therapies are not available. Previously we have shown in mice that a peptide which functionally mimics the human natural killer cell (HNK)-1 trisaccharide epitope significantly improves the outcome of femoral nerve injury. Here we evaluated the translational potential of this treatment using primates. We applied a linear HNK-1 mimetic or a functionally inactive control peptide in silicone cuffs used to reconstruct the cut femoral nerves of adult cynomolgus monkeys (\n                    <jats:italic toggle=\"yes\">Macaca fascicularis<\/jats:italic>\n                    ). Functional recovery was evaluated using video-based gait analysis over a 160-day observation period. The final outcome was further assessed using force measurements, H-reflex recordings, nerve histology, and ELISA to assess immunoreactivity to HNK-1 in the treated monkeys. Gait deficits were significantly reduced in HNK-1 mimetic-treated compared with control peptide-treated animals between 60 and 160 days after injury. Better outcome at 160 days after surgery in treated versus control animals was also confirmed by improved quadriceps muscle force, enhanced H-reflex amplitude, decreased H-reflex latency, and larger diameters of regenerated axons. No adverse reactions to the mimetic, in particular immune responses resulting in antibodies against the HNK-1 mimetic or immune cell infiltration into the damaged nerve, were observed. These results indicate the potential of the HNK-1 mimetic as an efficient, feasible, and safe adjunct treatment for nerve injuries requiring surgical repair in clinical settings.\n                  <\/jats:p>","DOI":"10.1089\/neu.2011.1775","type":"journal-article","created":{"date-parts":[[2011,4,4]],"date-time":"2011-04-04T08:27:45Z","timestamp":1301905665000},"page":"1295-1306","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Glycomimetic Improves Recovery after Femoral Injury in a Non-Human Primate"],"prefix":"10.1177","volume":"28","author":[{"given":"Andrey","family":"Irintchev","sequence":"first","affiliation":[{"name":"Universit\u00e4t Hamburg","place":["Germany"]},{"name":"Friedrich Schiller University Jena","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Mei","family":"Wu","sequence":"additional","affiliation":[{"name":"The Fourth Military Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Joon","family":"Lee","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Hamburg","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Kunming General Hospital of the Chinese PLA","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Ping","family":"Feng","sequence":"additional","affiliation":[{"name":"Kunming General Hospital of the Chinese PLA","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Sheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Kunming General Hospital of the Chinese PLA","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Bernreuther","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Hamburg","place":["Germany"]},{"name":"University of Hamburg","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Loers","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Hamburg","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Wei","family":"You","sequence":"additional","affiliation":[{"name":"The Fourth Military Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melitta","family":"Schachner","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Hamburg","place":["Germany"]},{"name":"Rutgers University"},{"name":"Shantou University Medical College","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,7]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.08.005"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.01341.x"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-07-02602.2000"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.12.016"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200601579"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00183-3"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-15-06631.2002"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-06-02730.1993"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199811)21:11<1405::AID-MUS7>3.0.CO;2-D"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.102.3.731"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702965200"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.12.018"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.102.3.844"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.4.1194"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02740621"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01402-9"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-211-72958-8_11"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp160"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0262"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04274.x"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200110000-00011"},{"key":"e_1_3_3_23_1","first-page":"87","article-title":"Anatomic and functional reorganization of somatosensory cortex in mature primates after peripheral nerve and spinal cord injury","volume":"93","author":"Kaas J.","year":"2003","unstructured":"Kaas J., , Collins C. 2003. Anatomic and functional reorganization of somatosensory cortex in mature primates after peripheral nerve and spinal cord injury. Adv. Neurol., 93:87\u201395.","journal-title":"Adv. Neurol."},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1349"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.02.012"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10054"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-1298(20)30469-7"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/316146a0"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/311153a0"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200007000-00005"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1085-9489.2003.03027.x"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1994.tb00570.x"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.040378"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1992.tb00171.x"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp128"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm155"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591577006300710"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05748.x"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200006)23:6<863::AID-MUS4>3.0.CO;2-0"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2285"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(95)93899-9"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01247.x"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20948"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1042\/BA20030173"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03052-9"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490250305"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06847.x"}],"container-title":["Journal of Neurotrauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/neu.2011.1775","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2011.1775","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2011.1775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:14:32Z","timestamp":1777673672000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/neu.2011.1775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1089\/neu.2011.1775"],"URL":"https:\/\/doi.org\/10.1089\/neu.2011.1775","relation":{},"ISSN":["0897-7151","1557-9042"],"issn-type":[{"value":"0897-7151","type":"print"},{"value":"1557-9042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}