{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:29:43Z","timestamp":1777926583964,"version":"3.51.4"},"reference-count":58,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Nerve injury in neonatal rats leads to considerable motoneuron death. We investigated whether treatment with riluzole (a presynaptic inhibitor of glutamate release) is able to enhance survival of motor units (MUs) in the slow soleus (Sol) and fast extensor digitorum longus (EDL) muscles after sciatic nerve crush in newborn rats. Examination of 3- to 4-month-old rats revealed a beneficial effect of riluzole treatment after injury carried out on the first day after birth. At this time increased MU survival occurred in both the Sol and EDL muscles. In rats with nerve injury carried out on the second day after birth, increased MU survival occurred only in the Sol. We conclude that although riluzole treatment can rescue motoneurons destined to die and improve muscle performance, its beneficial effect is age-dependent, and the difference between the rescue of Sol and EDL MUs may be due to the slower maturation of motoneurons to soleus muscle. These findings have important implications regarding the motoneuron properties required for riluzole's beneficial effect.<\/jats:p>","DOI":"10.1089\/neu.2011.2090","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T23:01:12Z","timestamp":1327014072000},"page":"1506-1517","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Riluzole Treatment Reduces Motoneuron Death Induced by Axotomy in Newborn Rats"],"prefix":"10.1177","volume":"29","author":[{"given":"Anna M.","family":"Cabaj","sequence":"first","affiliation":[{"name":"Institute of Biocybernetics and Biomedical Engineering PAS","place":["Poland"]},{"name":"Nencki Institute of Experimental Biology PAS","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urszula","family":"Slawinska","sequence":"additional","affiliation":[{"name":"Nencki Institute of Experimental Biology PAS","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-3472(75)90114-1"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198901000-00024"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(96)00249-7"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152710791292576"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1991.tb00082.x"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07579.x"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1964.sp007444"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3462-08.2009"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(96)01839-8"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00709-3"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(94)00088-Q"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.6_Suppl_4.233S"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1987.tb08064.x"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.55782\/ane-1998-1277"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(92)90129-K"},{"key":"e_1_3_3_17_1","first-page":"450","article-title":"Motoneurone survival: a functional approach","volume":"19","author":"Greensmith L.","year":"1996","unstructured":"Greensmith L., , Vrbov\u00e1 G. 1996. Motoneurone survival: a functional approach. Trends Neurosci., 19:450\u2013455.","journal-title":"Trends Neurosci."},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00072-5"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00335.2005"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(97)00072-2"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005628"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.18.8502"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-895X(24)12535-7"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005241"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.074138"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06211.x"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00120-1"},{"key":"e_1_3_3_28_1","first-page":"948","article-title":"Recent development in NMDA receptors","volume":"113","author":"Liu Y.","year":"2000","unstructured":"Liu Y., , Zhang J. 2000. Recent development in NMDA receptors. Chin. Med. J. (Engl.), 113:948\u2013956.","journal-title":"Chin. Med. J. (Engl.)"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90014-Y"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014364"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000112120"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.300.3.717"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.01.075"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90253-C"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(83)90152-9"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015270"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816X.2000.01362.x"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00489.x"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1445"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0115594"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90108-J"},{"key":"e_1_3_3_42_1","first-page":"117","article-title":"Motor localization and the effects of nerve injury on the ventral horn cells of the spinal cord","volume":"80","author":"Romanes G.J.","year":"1946","unstructured":"Romanes G.J. 1946. Motor localization and the effects of nerve injury on the ventral horn cells of the spinal cord. J. Anat., 80:117\u2013131.","journal-title":"J. Anat."},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017356"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10229"},{"key":"e_1_3_3_45_1","first-page":"25","article-title":"[Tolerability of riluzole: a review of the literature]","volume":"155","author":"Siniscalchi A.","year":"2004","unstructured":"Siniscalchi A. 2004. [Tolerability of riluzole: a review of the literature] Clin. Ter., 155:25\u201328.","journal-title":"Clin. Ter."},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(94)00053-C"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050393"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.124123"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00242.x"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.09.018"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90189-U"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.04.080"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(02)00195-9"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(00)00397-X"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.2000.00244.x"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.115.1.113"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00229036"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00749.x"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.70020677.x"}],"container-title":["Journal of Neurotrauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/neu.2011.2090","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2011.2090","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2011.2090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:15:39Z","timestamp":1777673739000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/neu.2011.2090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":58,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1089\/neu.2011.2090"],"URL":"https:\/\/doi.org\/10.1089\/neu.2011.2090","relation":{},"ISSN":["0897-7151","1557-9042"],"issn-type":[{"value":"0897-7151","type":"print"},{"value":"1557-9042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}