{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:29:44Z","timestamp":1777926584000,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>\n                    The optimal treatment strategy for ossification of the posterior longitudinal ligament (OPLL) depends on symptoms and is uncertain. Whether the risk of spinal cord injury (SCI) is increased in patients with cervical spinal stenosis or myelopathy caused by OPLL remains unclear. This study aimed to evaluate the risk of SCI in patients with OPLL of the cervical spine when managed with conservative treatment (no surgery). Study subjects were identified from a nationwide cohort of 26,544,883 people from 1998 to 2005 and were divided into the OPLL group (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =265), who were hospitalized for OPLL but had conservative treatment (no surgery), and the comparison group (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =5339), composed of age- and sex-matched people. Until the end of 2008, a total of 5604 subjects were followed-up for 34,723.5 person-years. The propensity score method was used to adjust for covariates. Kaplan-Meier and Cox regression analyses were performed. The incidence rate of cervical SCI in the OPLL group was found to be significantly higher than in the comparison group (4.81 versus 0.18 per 1000 person-years;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.001). Cervical SCI was more likely to happen in the OPLL group than in the comparison group (crude hazard ratio [HR] 25.64;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.001). After adjustments, the OPLL group had a 32.16-fold (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.001) higher risk for cervical SCI. Disability caused by SCI had an even higher risk (HR=110.72, adjusted HR=104.78;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.001) for the OPLL group. Therefore, cervical SCI and related disabilities are more likely to happen in OPLL patients, who should be cautioned for subsequent SCI if treated conservatively.\n                  <\/jats:p>","DOI":"10.1089\/neu.2011.2095","type":"journal-article","created":{"date-parts":[[2011,10,12]],"date-time":"2011-10-12T16:36:08Z","timestamp":1318437368000},"page":"462-468","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Conservatively Treated Ossification of the Posterior Longitudinal Ligament Increases the Risk of Spinal Cord Injury: A Nationwide Cohort Study"],"prefix":"10.1177","volume":"29","author":[{"given":"Jau-Ching","family":"Wu","sequence":"first","affiliation":[{"name":"National Yang-Ming University","place":["Taiwan"]},{"name":"Taipei Veterans General Hospital","place":["Taiwan"]},{"name":"National Yang-Ming University","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chun","family":"Chen","sequence":"additional","affiliation":[{"name":"National Yang-Ming University","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Liu","sequence":"additional","affiliation":[{"name":"Chang Gung Memorial Hospital","place":["Taiwan"]},{"name":"Chang Gung Memorial Hospital","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Cheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital","place":["Taiwan"]},{"name":"National Yang-Ming University","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzeng-Ji","family":"Chen","sequence":"additional","affiliation":[{"name":"National Yang-Ming University","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Shun","family":"Lo","sequence":"additional","affiliation":[{"name":"National Yang-Ming University","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peck-Foong","family":"Thien","sequence":"additional","affiliation":[{"name":"National Yang-Ming University","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrich","family":"Cheng","sequence":"additional","affiliation":[{"name":"National Yang-Ming University","place":["Taiwan"]},{"name":"Taipei Veterans General Hospital","place":["Taiwan"]},{"name":"National Yang-Ming University","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,2,10]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.C.01711"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2087"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/BSD.0b013e3181c7e91e"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.7.SPINE08965"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441836"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000215867.87770.73"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000083590.84053.CC"},{"key":"e_1_3_3_9_1","first-page":"168","article-title":"Pathogenesis of myelopathy in patients with ossification of the posterior longitudinal ligament","volume":"96","author":"Matsunaga S.","year":"2002","unstructured":"Matsunaga S., , Kukita M., , Hayashi K., , Shinkura R., , Koriyama C., , Sakou T., , Komiya S. 2002. 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