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We prepared an animal model of spinal adhesive arachnoiditis by injecting kaolin into the subarachnoid space at the eighth thoracic vertebra of rabbits. The animals were evaluated 4 months later. Of the 30 rabbits given kaolin injection into the cerebrospinal fluid, 23 showed complete circumferential obstruction. In the 7 animals with partial obstruction of the subarachnoid space, intramedullary changes were not observed. However, among the 23 animals showing complete obstruction of the subarachnoid space, dilatation of the central canal (hydromyelia) occurred in 21, and intramedullary syrinx (syringomyelia) was observed in 11. In animals with complete obstruction, fluorescence microscopy revealed intramedullary edema around the central canal, extending to the posterior columns. Electron microscopy of hydromyelia revealed a marked reduction of villi on the ependymal cells, separation of the ependymal cells, and cavitation of the subependymal layer. The dilated perivascular spaces indicate alterations of fluid exchange between the subarachnoid and extracellular spaces. Syringomyelia revealed that nerve fibers and nerve cells were exposed on the surface of the syrinx, and necrotic tissue was removed by macrophages to leave a syrinx. Both pathologies differ in their mechanism of development: hydromyelia is attributed to disturbed reflux of cerebrospinal fluid, while tissue necrosis due to disturbed intramedullary blood flow is considered to be involved in formation of the syrinx in syringomyelia.<\/jats:p>","DOI":"10.1089\/neu.2011.2259","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T12:01:09Z","timestamp":1332504069000},"page":"1803-1816","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Experimental Syringohydromyelia Induced by Adhesive Arachnoiditis in the Rabbit: Changes in the Blood\u2013Spinal Cord Barrier, Neuroinflammatory Foci, and Syrinx Formation"],"prefix":"10.1177","volume":"29","author":[{"given":"Shigeru","family":"Kobayashi","sequence":"first","affiliation":[{"name":"The University of Fukui","place":["Japan"]},{"name":"University of Fukui","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsura","family":"Kato","sequence":"additional","affiliation":[{"name":"Zengo Orthopedic Clinics","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Rodr\u00edguez Guerrero","sequence":"additional","affiliation":[{"name":"The University of Fukui","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisatoshi","family":"Baba","sequence":"additional","affiliation":[{"name":"The University of Fukui","place":["Japan"]},{"name":"University of Fukui","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidezo","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Retired."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,6,10]]},"reference":[{"issue":"1","key":"e_1_3_3_2_1","first-page":"1","article-title":"La syringomy\u00e9lie et les liquids intra-rachidiens","volume":"25","author":"Aboulker J.","year":"1979","unstructured":"Aboulker J. 1979. 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