{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T17:27:54Z","timestamp":1788715674198,"version":"build-2803163510"},"reference-count":63,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>\n                    The aim of this study was to evaluate the potential efficacy of the serotonin\n                    <jats:sub>1A<\/jats:sub>\n                    (5-HT\n                    <jats:sub>1A<\/jats:sub>\n                    ) receptor agonist buspirone (BUS) on behavioral and histological outcome after traumatic brain injury (TBI). Ninety-six isoflurane-anesthetized adult male rats were randomized to receive either a controlled cortical impact or sham injury, and then assigned to six TBI and six sham groups receiving one of five doses of BUS (0.01, 0.05, 0.1, 0.3, or 0.5\u2009mg\/kg) or saline vehicle (VEH, 1.0\u2009mL\/kg). Treatments began 24\u2009h after surgery and were administered intraperitoneally once daily for 3 weeks. Motor function (beam-balance\/beam-walk tests) and spatial learning\/memory (Morris water maze) were assessed on post-operative days 1\u20135 and 14\u201319, respectively. Morphologically intact CA1\/CA3 cells and cortical lesion volume were quantified at 3 weeks. No differences were observed among the BUS and VEH sham groups in any end-point measure and thus the data were pooled. Regarding the TBI groups, repeated-measures ANOVAs revealed that the 0.3 mg\/kg dose of BUS enhanced cognitive performance relative to VEH and the other BUS doses (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.05), but did not significantly impact motor function. Moreover, the same dose conferred selective histological protection as evidenced by smaller cortical lesions, but not greater CA1\/CA3 cell survival. No significant behavioral or histological differences were observed among the other BUS doses versus VEH. These data indicate that BUS has a narrow therapeutic dose response, and that 0.3\u2009mg\/kg is optimal for enhancing spatial learning and memory in this model of TBI. BUS may have potential as a novel pharmacotherapy for clinical TBI.\n                  <\/jats:p>","DOI":"10.1089\/neu.2012.2358","type":"journal-article","created":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T14:08:30Z","timestamp":1331734110000},"page":"1898-1907","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["Traumatic Brain Injury-Induced Cognitive and Histological Deficits Are Attenuated by Delayed and Chronic Treatment with the 5-HT\n                    <sub>1A<\/sub>\n                    -Receptor Agonist Buspirone"],"prefix":"10.1177","volume":"29","author":[{"given":"Adam S.","family":"Olsen","sequence":"first","affiliation":[{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher N.","family":"Sozda","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey P.","family":"Cheng","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann N.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony E.","family":"Kline","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,7,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858404267382"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01948-4"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.03.011"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/HTR.0b013e3181d6c715"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00010-6"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/01688638608401325"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.02.006"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.06.025"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2008.09.0120"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90182-N"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00503-2"},{"key":"e_1_3_3_13_1","first-page":"341","article-title":"BAY x 3702","volume":"22","author":"De Vry J.","year":"1997","unstructured":"De Vry J., , Dietrich H., , Glaser T., , Heine H.-G., , Horv\u00e1th E., , Jork R., , Maertins T., , Mauler F., , Opitz W., , Scherling D., , Schohe-Loop R., , Schwarz T. 1997. 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