{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:06:33Z","timestamp":1792098393049,"version":"4.4.0"},"reference-count":64,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>\n                    Nerve-related complications have been frequently reported in dental procedures, and a very frequent type of occurrence involves the inferior alveolar nerve (IAN). The nerve injury in humans often results in persistent pain accompanied by allodynia and hyperalgesia. In this investigation, we used an experimental IAN injury in rats, which was induced by a Crile hemostatic clamp, to evaluate the effects of laser therapy on nerve repair. We also studied the nociceptive behavior (von Frey hair test) before and after the injury and the behavioral effects of treatment with laser therapy (emitting a wavelength of 904\u2009nm, output power of 70\u2009Wpk, a spot area of \u223c0.1\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    , frequency of 9500\u2009Hz, pulse time 60 ns and an energy density of 6\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ). As neurotrophins are essential for the process of nerve regeneration, we used immunoblotting techniques to preliminarily examine the effects of laser therapy on the expression of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). The injured animals treated with laser exhibited an improved nociceptive behavior. In irradiated animals, there was an enhanced expression of NGF (53%) and a decreased BDNF expression (40%) after laser therapy. These results indicate that BDNF plays a locally crucial role in pain-related behavior development after IAN injury, increasing after lesions (in parallel to the installation of pain behavior) and decreasing with laser therapy (in parallel to the improvement of pain behavior). On the other hand, NGF probably contributes to the repair of nerve tissue, in addition to improving the pain-related behavior.\n                  <\/jats:p>","DOI":"10.1089\/neu.2012.2603","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T06:23:59Z","timestamp":1354170239000},"page":"480-486","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":38,"title":["Laser Therapy and Pain-Related Behavior after Injury of the Inferior Alveolar Nerve: Possible Involvement of Neurotrophins"],"prefix":"10.1177","volume":"30","author":[{"given":"Daniel","family":"de Oliveira Martins","sequence":"first","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Martinez dos Santos","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Brazil"]},{"name":"University Nove de Julho","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Evany de Oliveira","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz R.G.","family":"de Britto","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Benedito Dias Lemos","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marucia","family":"Chacur","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,3,15]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"570","volume-title":"Laser Therapy. 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