{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:53:12Z","timestamp":1784771592921,"version":"3.55.0"},"reference-count":58,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>Chronic neuropathic pain is a significant consequence of spinal cord injury (SCI) that is associated with evoked pain, including allodynia and\/or hyperalgesia. Allodynia is defined as a painful response to normally innocuous stimuli, and hyperalgesia occurs when there is an amplified pain response to normally noxious stimuli. We describe a model of a unilateral cervical level (C5) contusion injury where sensory recovery was assessed weekly for 6 weeks in 32 adult, female, Sprague-Dawley rats. Bilateral thermal hyperalgesia and tactile allodynia are detectable in the fore- and hindpaws as early as 7 days post-injury (dpi) and persist for at least 42 days. Paw withdrawal latency in response to a noxious thermal stimulus significantly intra-animal pre-operative values. Change in paw withdrawal latency plateaued at 21\u2009dpi. Interestingly, bilateral forepaw allodynia develops in fewer than 40% of rats as measured by von Frey monofilament testing. Similar results occur in the hindpaws, where bilateral allodynia occurs in 46% of rats with SCI. The contralesional forepaw and both hindpaws of rats showed a slight increase in paw withdrawal threshold to tactile stimuli acutely after SCI, corresponding to ipsilesional forelimb motor deficits that resolve over time. That there is no difference among allodynic and non-allodynic groups in overall spared tissue or specifically of the dorsal column or ventrolateral white matter where ascending sensory tracts reside suggests that SCI-induced pain does not depend solely on the size or extent of the lesion, but that other mechanisms are in play. These observations provide a valid model system for future testing of therapeutic interventions to prevent the onset or to reduce the debilitating effects of chronic neuropathic pain after SCI.<\/jats:p>","DOI":"10.1089\/neu.2012.2632","type":"journal-article","created":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T12:45:20Z","timestamp":1354797920000},"page":"884-890","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":59,"title":["Chronic At- and Below-Level Pain after Moderate Unilateral Cervical Spinal Cord Contusion in Rats"],"prefix":"10.1177","volume":"30","author":[{"given":"Megan Ryan","family":"Detloff","sequence":"first","affiliation":[{"name":"Drexel University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Rodel E.","family":"Wade","sequence":"additional","affiliation":[{"name":"Drexel University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Houl\u00e9","sequence":"additional","affiliation":[{"name":"Drexel University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,5,15]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Christopher and Dana Reeve Foundation. 2013. Paralysis facts and figures. http:\/\/www.christopherreeve.org. 2013May."},{"key":"e_1_3_3_3_2","unstructured":"University of Alabama Spinal Cord Injury Model System Information Network. 2013. http:\/\/www.uab.edu\/medicine\/sci\/uab-scims-information\/sci-infosheets. 2013May."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200012000-00037"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101116"},{"key":"e_1_3_3_6_2","first-page":"77","article-title":"Clinical characteristics of central (dysesthetic) pain in spinal cord injury patients","author":"Davidoff G.","year":"1991","unstructured":"Davidoff G., , Roth E.J. 1991. Clinical characteristics of central (dysesthetic) pain in spinal cord injury patients. Pain and Central Nervous System Disease: The Central Pain Syndromes. Raven Press: New York, 77\u201383.","journal-title":"Pain and Central Nervous System Disease: The Central Pain Syndromes"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(96)03224-1"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/0899022031000083843"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg007"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.06.001"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3102022"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00452-9"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200205000-00004"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2008.64"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101511"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.07.009"},{"key":"e_1_3_3_17_2","first-page":"e3247","article-title":"Acute and chronic tactile sensory testing after spinal cord injury in rats","volume":"62","author":"Detloff M.R.","year":"2012","unstructured":"Detloff M.R., , Fisher L.C., , Deibert R.J., , Basso D.M. 2012. Acute and chronic tactile sensory testing after spinal cord injury in rats. J. Vis. Exp., 62:e3247.","journal-title":"J. Vis. Exp."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.04.066"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.04.009"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00961-2"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2008.0750"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00330"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/08977150360547099"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90026-7"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1995.12.1"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.11.029"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(73)90105-2"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(92)90070-R"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(81)90190-1"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.09.016"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/154596830001400405"},{"key":"e_1_3_3_32_2","doi-asserted-by":"crossref","unstructured":"Willis W.D.Jr. Coggeshall R.E. 1991. Sensory Mechanisms of the Spinal Cord. 2nd. Plenum Press: New York 401.","DOI":"10.1007\/978-1-4899-0597-0_10"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903130212"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903610204"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902830410"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1195"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1682"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/306686a0"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/355075a0"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903600109"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-25-08752.2003"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2005.11753804"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101670"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.23.281"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00101-3"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901580103"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2003.07.002"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)37009-2"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1089\/08977150152693782"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.01.011"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6608"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.12.022"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1114\/B:ABME.0000042228.89106.48"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0003-06.2006"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.05.025"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.01.003"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026054367593"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00491-3"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn2069"}],"container-title":["Journal of Neurotrauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/neu.2012.2632","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2012.2632","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2012.2632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:17:32Z","timestamp":1777673852000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/neu.2012.2632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":58,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1089\/neu.2012.2632"],"URL":"https:\/\/doi.org\/10.1089\/neu.2012.2632","relation":{},"ISSN":["0897-7151","1557-9042"],"issn-type":[{"value":"0897-7151","type":"print"},{"value":"1557-9042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}