{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:26:43Z","timestamp":1791192403705,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>\n                    Adequate nutritional support is a major challenge in brain injury patients, because malnutrition cannot be reversed by standard enteral nutrition. We hypothesized that an oligomeric formula could improve nutritional status by restoring intestinal trophicity. Eighteen male Sprague-Dawley rats (300\u2013330\u2009g) underwent gastrostomy on day \u22127 (D-7) and traumatic brain injury (TBI) by hydraulic percussion (D0) and were then fed for 4 days with either a polymeric formula (Sondalis\n                    <jats:sup>\u00ae<\/jats:sup>\n                    HP, TBIP,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =9), or an oligomeric formula (Peptamen\n                    <jats:sup>\u00ae<\/jats:sup>\n                    HN, TBIO,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =9). In addition, a control group of healthy gastrostomized rats was fed the polymeric diet (control,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =8). All rats were weighed daily. On D+4, the rats were euthanized. Blood was collected for plasma amino acid determination. Organs were removed and weighed. Intestinal morphometry was studied. Protein content was assessed on intestine and muscles. Enterobacterial translocation and dissemination were evaluated. Results were expressed as means\u00b1SEM and compared using analysis of variance+Newman-Keuls test. TBI induced a significant decrease in whole body weight (TBIP vs. control,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.05) that was totally blunted by the oligomeric diet (TBIP vs. TBIO,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.01). Thymus weight significantly decreased after TBI (TBIP vs. control,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.05) and was restored by the oligomeric formula (TBIO vs. TBIP,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.05). Glutamine (GLN) concentration was improved by the oligomeric diet in both plasma (TBIO: 688\u00b119 vs. control: 591\u00b145 and TBIP: 615\u00b142\u2009\u03bcmol\/L,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.05) and soleus muscle. These results show that the use of an oligomeric diet may limit response to injury after brain injury and could be a simple nutritional strategy in this setting.\n                  <\/jats:p>","DOI":"10.1089\/neu.2012.2707","type":"journal-article","created":{"date-parts":[[2012,11,27]],"date-time":"2012-11-27T15:06:27Z","timestamp":1354028787000},"page":"975-980","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["An Oligomeric Diet Limits the Response to Injury in Traumatic Brain-Injured Rats"],"prefix":"10.1177","volume":"30","author":[{"given":"Christophe","family":"Moinard","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Descartes","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Delpierre","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes","place":["France"]},{"name":"H\u00f4pital Saint-Antoine","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Lo\u00ef","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Neveux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes","place":["France"]},{"name":"APHP","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Jos\u00e9","family":"Butel","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie","place":["France"]},{"name":"Universit\u00e9 Paris Descartes","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Cynober","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes","place":["France"]},{"name":"APHP","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Charrueau","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,6,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.7.2714"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1990.7.77"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2008.0737"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2006.02.003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0624-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-005-3034-3"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i12.2776"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2004.08.002"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.11.1277"},{"key":"e_1_3_3_11_2","first-page":"406","article-title":"Improvement in protein absorption with a small-peptide-based diet in patients with high jejunostomy","volume":"8","author":"Cosnes J.","year":"1992","unstructured":"Cosnes J., , Evard D., , Beaugerie L., , Gendre J.P., , Le Quintrec Y. 1992. Improvement in protein absorption with a small-peptide-based diet in patients with high jejunostomy. Nutrition, 8:406\u2013411.","journal-title":"Nutrition"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/67.1.124"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/014860710603000101"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/49.1.71"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0261-5614(91)90081-M"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2489-9"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508043389"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.1862"},{"key":"e_1_3_3_19_2","first-page":"17","volume-title":"Metabolic and Therapeutic Aspects of Amino Acids in Clinical Nutrition","author":"Neveux N.","year":"2004","unstructured":"Neveux N., , David P., , Cynober L. 2004. Measurement of amino acid concentration in biological fluids and tissues using ion-exchange chromatography. Metabolic and Therapeutic Aspects of Amino Acids in Clinical Nutrition. Cynober L. CRC Press: Boca Raton, 17\u201328."},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(00)00476-7"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-92271-3_103"},{"issue":"2","key":"e_1_3_3_22_2","first-page":"S27","article-title":"The use of immune enhancing diet in head injury","volume":"25","author":"Martindale R.G.","year":"2001","unstructured":"Martindale R.G., , Cresci G.A. 2001. The use of immune enhancing diet in head injury. JPEN J. Parenter. Enteral Nutr., 25,Suppl 2:S27\u2013S28.","journal-title":"JPEN J. Parenter. 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