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This study examines the independent effects of concussion on persistent symptoms. The Defense Automated Neurobehavioral Assessment, a clinical decision support tool, was used to assess neurobehavioral functioning in 646 United States Marines, all of whom were fit for duty. Marines were assessed for concussion history, post-concussive symptoms, emotional distress, neurocognitive functioning, and deployment history. Results showed that a recent concussion or ever having experienced a concussion was associated with an increase in emotional distress, but not with persistent post-concussive symptoms (PPCS) or neurocognitive functioning. Having had multiple lifetime concussions, however, was associated with greater emotional distress, PPCS, and reduced neurocognitive functioning that needs attention and rapid discrimination, but not for memory-based tasks. These results are independent of deployment history, combat exposure, and symptoms of post-traumatic stress disorder and depression. Results supported earlier findings that a previous concussion is not generally associated with post-concussive symptoms independent of covariates. In contrast with other studies that failed to find a unique contribution for concussion to PPCS, however, evidence of recent and multiple concussion was seen across a range of emotional distress, post-concussive symptoms, and neurocognitive functioning in this study population. Results are discussed in terms of implications for assessing concussion on return from combat.<\/jats:p>","DOI":"10.1089\/neu.2014.3363","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T19:08:57Z","timestamp":1404846537000},"page":"1823-1834","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":70,"title":["The Impact of Multiple Concussions on Emotional Distress, Post-Concussive Symptoms, and Neurocognitive Functioning in Active Duty United States Marines Independent of Combat Exposure or Emotional Distress"],"prefix":"10.1177","volume":"31","author":[{"given":"James L.","family":"Spira","sequence":"first","affiliation":[{"name":"University of Hawaii"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna E.","family":"Lathan","sequence":"additional","affiliation":[{"name":"AnthroTronix, Inc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Bleiberg","sequence":"additional","affiliation":[{"name":"Walter Reed National Military Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack W.","family":"Tsao","sequence":"additional","affiliation":[{"name":"U.S. Navy Bureau of Medicine and Surgery Falls Church"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,11,15]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"National Center for Injury Prevention and Control (2003). 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