{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:41:04Z","timestamp":1793144464188,"version":"4.5.0"},"reference-count":80,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>\n                    We evaluated the hypothesis that nutritive needs of injured brains are supported by large and coordinated increases in lactate shuttling throughout the body. To that end, we used dual isotope tracer ([6,6-\n                    <jats:sup>2<\/jats:sup>\n                    H2]glucose, i.e., D\n                    <jats:sub>2<\/jats:sub>\n                    -glucose, and [3-\n                    <jats:sup>13<\/jats:sup>\n                    C]lactate) techniques involving central venous tracer infusion along with cerebral (arterial [art] and jugular bulb [JB]) blood sampling. Patients with traumatic brain injury (TBI) who had nonpenetrating head injuries (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =12, all male) were entered into the study after consent of patients' legal representatives. Written and informed consent was obtained from healthy controls (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =6, including one female). As in previous investigations, the cerebral metabolic rate (CMR) for glucose was suppressed after TBI. Near normal arterial glucose and lactate levels in patients studied 5.7\u00b12.2 days (range of days 2\u201310) post-injury, however, belied a 71% increase in systemic lactate production, compared with control, that was largely cleared by greater (hepatic+renal) glucose production. After TBI, gluconeogenesis from lactate clearance accounted for 67.1% of glucose rate of appearance (Ra), which was compared with 15.2% in healthy controls. We conclude that elevations in blood glucose concentration after TBI result from a massive mobilization of lactate from corporeal glycogen reserves. This previously unrecognized mobilization of lactate subserves hepatic and renal gluconeogenesis. As such, a lactate shuttle mechanism indirectly makes substrate available for the body and its essential organs, including the brain, after trauma. In addition, when elevations in arterial lactate concentration occur after TBI, lactate shuttling may provide substrate directly to vital organs of the body, including the injured brain.\n                  <\/jats:p>","DOI":"10.1089\/neu.2014.3482","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:25:44Z","timestamp":1412346344000},"page":"811-819","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":54,"title":["Endogenous Nutritive Support after Traumatic Brain Injury: Peripheral Lactate Production for Glucose Supply via Gluconeogenesis"],"prefix":"10.1177","volume":"32","author":[{"given":"Thomas C.","family":"Glenn","sequence":"first","affiliation":[{"name":"University of California"},{"name":"UCLA Center for Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil A.","family":"Martin","sequence":"additional","affiliation":[{"name":"University of California"},{"name":"UCLA Center for Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"McArthur","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Hovda","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Vespa","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Johnson","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Horning","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Brooks","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,6,1]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"208","volume-title":"Comparative Physiology and Biochemistry: Current Topics and Trends","author":"Brooks G.A.","year":"1984","unstructured":"Brooks G.A. 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