{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:40:11Z","timestamp":1789101611678,"version":"build-2803163510"},"reference-count":21,"publisher":"SAGE Publications","issue":"17","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>\n                    Midline shift following severe traumatic brain injury (sTBI) detected on computed tomography (CT) scans is an established predictor of poor outcome. We hypothesized that lateral ventricular volume (LVV) asymmetry is an earlier sign of developing asymmetric intracranial pathology than midline shift. This retrospective analysis was performed on data from 84 adults with blunt sTBI requiring a ventriculostomy who presented to a Level I trauma center. Seventy-six patients underwent serial CTs within 3\u2009h and an average of three scans within the first 10\u2009d of sTBI. Left and right LVVs were quantified by computer-assisted manual volumetric measurements. LVV ratios (LVR) were determined on the admission CT to evaluate ventricular asymmetry. The relationship between the admission LVR value and subsequent midline shift development was tested using receiver operating characteristic (ROC) analysis, and odds ratio (OR) and relative risk tests. Sixty patients had no &gt;5\u2009mm midline shift on the initial admission scan. Of these, 15 patients developed it subsequently (16 patients already had &gt;5\u2009mm midline shift on admission scans). For &gt;5\u2009mm midline shift development, admission LVR of &gt;1.67 was shown to have a sensitivity of 73.3% and a specificity of 73.3% (area under the curve=0.782;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.0001). LVR of &gt;1.67 as exposure yielded an OR of 7.56 (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.01), and a risk ratio of 4.42 (p&lt;0.01) for midline shift development as unfavorable outcome. We propose that LVR captures LVV asymmetry and is not only related to, but also predicts the development of midline shift already at admission CT examination. Lateral ventricles may have a higher \u201ccompliance\u201d than midline structures to developing asymmetric brain pathology. LVR analysis is simple, rapidly accomplished and may allow earlier interventions to attenuate midline shift and potentially improve ultimate outcomes.\n                  <\/jats:p>","DOI":"10.1089\/neu.2014.3696","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T21:15:23Z","timestamp":1425935723000},"page":"1307-1311","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Lateral Ventricle Volume Asymmetry Predicts Midline Shift in Severe Traumatic Brain Injury"],"prefix":"10.1177","volume":"32","author":[{"given":"Arnold","family":"T\u00f3th","sequence":"first","affiliation":[{"name":"University of P\u00e9cs","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Schmalfuss","sequence":"additional","affiliation":[{"name":"University of Florida"},{"name":"North Florida\/South Georgia Veterans Administration"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley C.","family":"Heaton","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gabrielli","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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