{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:11:50Z","timestamp":1791893510328,"version":"4.3.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"16","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>\n                    Neuroendocrine disturbances are common after traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH), but only a few data exist on long-term anterior pituitary deficiencies after brain injury. We present data from the Structured Data Assessment of Hypopituitarism after TBI and SAH, a multi-center study including 1242 patients. We studied a subgroup of 351 patients, who had sustained a TBI (245) or SAH (106) at least 1 year before endocrine assessment (range 1\u201355 years) in a separate analysis. The highest prevalence of neuroendocrine disorders was observed 1\u20132 years post-injury, and it decreased over time only to show another maximum in the long-term phase in patients with brain injury occurring \u22655 years prior to assessment. Gonadotropic and somatotropic insufficiencies were most common. In the subgroup from 1 to 2 years after brain injury (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u2009126), gonadotropic insufficiency was the most common hormonal disturbance (19%, 12\/63 men) followed by somatotropic insufficiency (11.5%, 7\/61), corticotropic insufficiency (9.2%, 11\/119), and thyrotropic insufficiency (3.3%, 4\/122). In patients observed \u2265 5\u2009years after brain injury, the prevalence of somatotropic insufficiency increased over time to 24.1%, whereas corticotropic and thyrotrophic insufficiency became less frequent (2.5% and 0%, respectively). The prevalence differed regarding the diagnostic criteria (laboratory values vs. physician`s diagnosis vs. stimulation tests). Our data showed that neuroendocrine disturbances are frequent even years after TBI or SAH, in a cohort of patients who are still on medical treatment.\n                  <\/jats:p>","DOI":"10.1089\/neu.2015.4109","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T09:33:24Z","timestamp":1456392804000},"page":"1544-1553","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Neuroendocrine Disturbances One to Five or More Years after Traumatic Brain Injury and Aneurysmal Subarachnoid Hemorrhage: Data from the German Database on Hypopituitarism"],"prefix":"10.1177","volume":"33","author":[{"given":"Carmen","family":"Krewer","sequence":"first","affiliation":[{"name":"Sch\u00f6n Klinik Bad Aibling","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Schneider","sequence":"additional","affiliation":[{"name":"Sch\u00f6n Klinik Bad 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