{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:02:11Z","timestamp":1793221331927,"version":"4.5.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"18","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>\n                    Bladder-related events, including neurogenic detrusor overactivity, are the leading cause of autonomic dysreflexia in spinal cord injured individuals. Self-reported autonomic dysreflexia is reduced following onabotulinumtoxinA treatment for neurogenic detrusor overactivity; however, none of these trials have assessed autonomic dysreflexia events using the clinical cutoff of an increase in systolic blood pressure \u226520\u2009mm Hg. This study used a prospective, open-labelled design from 2013 to 2014 to quantitatively assess the efficacy of one cycle 200\u2009U intradetrusor-injected onabotulinumtoxinA (20 sites) on reducing the severity and frequency of bladder-related autonomic dysreflexia events and improving quality of life. Twelve men and five women with chronic, traumatic spinal cord injuries at or above the sixth thoracic level, and concomitant autonomic dysreflexia and neurogenic detrusor overactivity, underwent blood pressure monitoring during urodynamics and over a 24\u2009h period using ambulatory blood pressure monitoring pre- and 1 month post-treatment. Post-onabotulinumtoxinA, autonomic dysreflexia severity was reduced during urodynamics (systolic blood pressure increase: 42\u2009\u00b1\u200923\u2009mm Hg vs. 20\u2009\u00b1\u200910\u2009mm Hg,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and during bladder-related events across the 24\u2009h period (systolic blood pressure increase: 49\u2009\u00b1\u20092\u2009mm Hg vs. 26\u2009\u00b1\u200922\u2009mm Hg,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.004). Frequency of 24\u2009h bladder-related autonomic dysreflexia events was also decreased post-onabotulinumtoxinA (4\u2009\u00b1\u20092 events vs. 1\u2009\u00b1\u20091 events,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Autonomic dysreflexia and incontinence quality of life indices were also improved post-onabotulinumtoxinA (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Intradetrusor injections of onabotulinumtoxinA for the management of neurogenic detrusor overactivity in individuals with high level spinal cord injuries decreased the severity and frequency of bladder-related episodes of autonomic dysreflexia, and improved bladder function and quality of life.\n                  <\/jats:p>","DOI":"10.1089\/neu.2015.4278","type":"journal-article","created":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T06:56:34Z","timestamp":1458111394000},"page":"1651-1657","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Reduction in Bladder-Related Autonomic Dysreflexia after OnabotulinumtoxinA Treatment in Spinal Cord Injury"],"prefix":"10.1177","volume":"33","author":[{"given":"Ren\u00e9e J.","family":"Fougere","sequence":"first","affiliation":[{"name":"University of British Columbia","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine D.","family":"Currie","sequence":"additional","affiliation":[{"name":"University of British Columbia","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K.","family":"Nigro","sequence":"additional","affiliation":[{"name":"University of British Columbia","place":["Canada"]},{"name":"University of British Columbia","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Stothers","sequence":"additional","affiliation":[{"name":"University of British Columbia","place":["Canada"]},{"name":"University of British Columbia","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rapoport","sequence":"additional","affiliation":[{"name":"University of British Columbia","place":["Canada"]},{"name":"University of British Columbia","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei V.","family":"Krassioukov","sequence":"additional","affiliation":[{"name":"University of British Columbia","place":["Canada"]},{"name":"University of British Columbia","place":["Canada"]},{"name":"University of British Columbia","place":["Canada"]},{"name":"G.F. Strong Rehabilitation Centre","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,9,15]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"839","volume-title":"Autonomic Failure: A Textbook of Clinical Disorders of the Autonomic Nervous System","author":"Mathias C.J.","year":"2002","unstructured":"Mathias C.J., , andBannister R. (2002). Autonomic disturbances in spinal cord lesions. in: Autonomic Failure: A Textbook of Clinical Disorders of the Autonomic Nervous System. Bannister R., , and Mathias C.J. (eds.). 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