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These include changes to diffusion tensor imaging (DTI) parameters, absence of anatomical lesions on conventional neuroimaging, and neurobehavioral deficits. The Maryland closed head TBI model causes anterior-posterior plus sagittal rotational acceleration of the brain, frequently observed with motor vehicle and sports-related TBI injuries. The injury reflects a concussive injury model without skull fracture. The goal of our study was to characterize the acute (72\u2009h) pathophysiological changes occurring following a single mTBI using magnetic resonance imaging (MRI), behavioral assays, and histology. We assessed changes in fractional anisotropy (FA), mean (MD), longitudinal (LD), and radial (RD) diffusivities relative to pre-injury baseline measures. Significant differences were observed in both the longitudinal and radial diffusivities in the fimbria compared with baseline. A significant difference in radial diffusivity was also observed in the splenium of the corpus callosum compared with baseline. The exploratory activity of the mTBI animals was also assessed using computerized activity monitoring. A significant decrease was observed in ambulatory distance, average velocity, stereotypic counts, and vertical counts compared with baseline. Histological examination of the mTBI brain sections indicated a significant decrease in the expression of myelin basic protein in the fimbria, splenium, and internal capsule. Our findings demonstrate the vulnerability of the white matter tracts, specifically the fimbria and splenium, and the ability of DTI to identify changes to the integrity of the white matter tracts following mTBI.<\/jats:p>","DOI":"10.1089\/neu.2016.4407","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T22:23:37Z","timestamp":1462227817000},"page":"291-299","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Acute White Matter Tract Damage after Frontal Mild Traumatic Brain Injury"],"prefix":"10.1177","volume":"34","author":[{"given":"Juan J.","family":"Herrera","sequence":"first","affiliation":[{"name":"The University of Texas Health Science Center at Houston (UTHealth)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Bockhorst","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston (UTHealth)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakuntala","family":"Kondraganti","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston (UTHealth)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Stertz","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston (UTHealth)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Quevedo","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston (UTHealth)"},{"name":"The University of Texas Health Science Center at Houston (UTHealth)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ponnada A.","family":"Narayana","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston (UTHealth)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,1,15]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Faul M. 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