{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:41:18Z","timestamp":1788385278082,"version":"build-2803163510"},"reference-count":108,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>\n                    Environmental enrichment (EE) enhances cognition after traumatic brain injury (TBI). Galantamine (GAL) is an acetylcholinesterase inhibitor that also may promote benefits. Hence, the aims of this study were to assess the efficacy of GAL alone (standard [STD] housing) and in combination with EE in adult male rats after TBI. The hypothesis was that both therapies would confer motor, cognitive, and histological benefits when provided singly, but that their combination would be more efficacious. Anesthetized rats received a controlled cortical impact or sham injury, then were randomly assigned to receive GAL (1, 2, or 3\u2009mg\/kg; intraperitoneally [i.p.]) or saline vehicle (VEH; 1\u2009mL\/kg; i.p.) beginning 24\u2009h after surgery and once daily for 21 days (experiment 1). Motor (beam-balance\/walk) and cognitive (Morris water maze [MWM]) assessments were conducted on post-operative Days 1\u20135 and 14\u201319, respectively. Cortical lesion volumes were quantified on Day 21. Sham controls were better versus all TBI groups. No differences in motor function or lesion volumes were observed among the TBI groups (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&gt;\u20090.05). In contrast, GAL (2\u2009mg\/kg) enhanced MWM performance versus VEH and GAL (1 and 3\u2009mg\/kg;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In experiment 2, GAL (2\u2009mg\/kg) or VEH was combined with EE and the data were compared with the STD-housed groups from experiment 1. EE alone enhanced motor performance over the VEH-treated and GAL-treated (2\u2009mg\/kg) STD-housed groups (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Moreover, both EE groups (VEH or GAL) facilitated spatial learning and reduced lesion size versus STD + VEH controls (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). No additional benefits were observed with the combination paradigm, which does not support the hypothesis. Overall, the data demonstrate that EE and once daily GAL (2\u2009mg\/kg) promote cognitive recovery after TBI. Importantly, the combined therapies did not negatively affect outcome and thus this therapeutic protocol may have clinical utility.\n                  <\/jats:p>","DOI":"10.1089\/neu.2016.4790","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T23:34:47Z","timestamp":1478129687000},"page":"1610-1622","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Galantamine and Environmental Enrichment Enhance Cognitive Recovery after Experimental Traumatic Brain Injury But Do Not Confer Additional Benefits When Combined"],"prefix":"10.1177","volume":"34","author":[{"given":"Patricia B.","family":"de la Tremblaye","sequence":"first","affiliation":[{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina O.","family":"Bondi","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naima","family":"Lajud","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"},{"name":"Mexican Social Security Institute","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey P.","family":"Cheng","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah L.","family":"Radabaugh","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony E.","family":"Kline","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,4,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-003-0074-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1996.13.181"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)02069-1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.15.1.17"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1998.15.295"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2174\/138945012800398964"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01310-8"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.09.062"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90034-0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/089771502762300238"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1535"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3445"},{"key":"e_1_3_3_14_2","first-page":"10","article-title":"Targeting alpha7 nicotinic acetylcholine receptors: a future neurotprotection from traumatic brain injury","volume":"10","author":"Shin S.S.","year":"2015","unstructured":"Shin S.S., and Dixon C.E. 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