{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:20:59Z","timestamp":1789852859195,"version":"4.0.1"},"reference-count":37,"publisher":"SAGE Publications","issue":"18","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>\n                    The aim of this study was to characterize autonomic lesions in participants with spinal cord injury (SCI;\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200910) using an autonomic reflex screen, incorporating sudomotor, cardiovagal, and sympathetic adrenergic tests, as well as hemodynamic responses to head-up tilt (HUT). Hemodynamic responses were compared to healthy controls (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200920) and previously published normative cutoffs in order better identify autonomic impairments. Sympathetic skin responses (SSRs), heart rate response to deep breathing (HR\n                    <jats:sub>DB<\/jats:sub>\n                    ), and heart rate and beat-to-beat blood pressure responses to Valsalva maneuver (VM) and HUT were measured. SCI participants demonstrated impairment in at least one domain, with 7 of 10 demonstrating autonomic impairment across all domains. No single test was concordant with orthostatic hypotension on HUT, in all participants. Measures of cardiovagal function, including HR\n                    <jats:sub>DB<\/jats:sub>\n                    (SCI\u2009=\u20097.7\u2009\u00b1\u20093.8 beats\/min vs. controls\u2009=\u200917.6\u2009\u00b1\u20098.1 beats\/min) and Valsalva ratio (SCI\u2009=\u20091.53\u2009\u00b1\u20090.29 vs. controls\u2009=\u20091.85\u2009\u00b1\u20090.37), were significantly reduced in SCI participants, compared to controls (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). These findings suggest that an autonomic reflex screen, which includes standardized testing protocol and normative data for comparison, is useful for determining the autonomic domains affected by the neurological injury in SCI. We also demonstrated significant cardiovagal impairment in SCI participants compared to controls, which warrants further investigation to determine whether cardiovagal dysfunction is associated with the negative cardiovascular outcomes, which are known to occur in SCI.\n                  <\/jats:p>","DOI":"10.1089\/neu.2016.4888","type":"journal-article","created":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T11:05:11Z","timestamp":1495623911000},"page":"2624-2633","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Multi-Domain Assessment of Autonomic Function in Spinal Cord Injury Using a Modified Autonomic Reflex Screen"],"prefix":"10.1177","volume":"34","author":[{"given":"Michael J.","family":"Berger","sequence":"first","affiliation":[{"name":"University of British Columbia","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Kimpinski","sequence":"additional","affiliation":[{"name":"Western University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine D.","family":"Currie","sequence":"additional","affiliation":[{"name":"University of Toronto","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirmand","family":"Nouraei","sequence":"additional","affiliation":[{"name":"University of British Columbia","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Wayne State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei V.","family":"Krassioukov","sequence":"additional","affiliation":[{"name":"University of British Columbia","place":["Canada"]},{"name":"International Collaboration On Repair Discoveries (ICORD)","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,9,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.08.003"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101089"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a1aa68"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.3903"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1179\/204577211X13207446293695"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-2005-00319"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2010.06.006"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1310\/sci1904-267"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2008.87"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(02)00207-2"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3373"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-011-0132-8"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.23.1713"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11144-8"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-012-0349-8"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-817725"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100016000"},{"key":"e_1_3_3_19_2","first-page":"2502","article-title":"Quantitative autonomic testing","volume":"53","author":"Novak P.","year":"2011","unstructured":"Novak P. (2011). Quantitative autonomic testing. J. Vis. Exp. (53), 2502.","journal-title":"J. Vis. Exp."},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.02.023"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-016-0370-x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31829e46f3"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00290.2015"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02291236"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.4103\/0972-2327.112479"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.50.10.1253"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-015-0276-z"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2012.2507"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02281623"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-002-0068-0"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-006-0352-5"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.01.038"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02291358"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2015.10.047"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02267821"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821e5563"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2016.04.006"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2014.05.002"}],"container-title":["Journal of Neurotrauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/neu.2016.4888","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2016.4888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2016.4888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:27:11Z","timestamp":1777674431000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/neu.2016.4888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":37,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1089\/neu.2016.4888"],"URL":"https:\/\/doi.org\/10.1089\/neu.2016.4888","relation":{},"ISSN":["0897-7151","1557-9042"],"issn-type":[{"value":"0897-7151","type":"print"},{"value":"1557-9042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9]]}}}