{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:11:05Z","timestamp":1787008265506,"version":"build-2736575974"},"reference-count":60,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:00:00Z","timestamp":1553040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>\n                    Post-traumatic stress disorder (PTSD) is commonly observed in military service members with mild traumatic brain injury (mTBI); however, the relationship between mTBI and PTSD is complex and not well understood. The present study aims to elucidate a link between the degree of alteration in limbic system-related white matter tracts and PTSD symptoms in an mTBI population. Diffusion-tensor imaging (DTI) with probabilistic tractography of the fronto-limbic pathways revealed decreased white matter integrity in the uncinate fasciculus in those with co-morbid mTBI and PTSD (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200934), relative to those with only mTBI (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200935). Additionally, fractional anisotropy (FA) and radial diffusivity (RD) measures in the bilateral uncinate fasciculus correlated with Post-Traumatic Stress Disorder Checklist Civilian version (PCL-C) scores, and primarily within the avoidance and re-experiencing domains. Findings from this study suggest the degree of traumatic injury within the limbic system could be directly related to post-traumatic stress and post-concussive symptoms, with disrupted white matter leading to significant PTSD outcomes.\n                  <\/jats:p>","DOI":"10.1089\/neu.2017.5541","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T07:39:56Z","timestamp":1532417996000},"page":"1093-1098","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Decreases in White Matter Integrity of Ventro-Limbic Pathway Linked to Post-Traumatic Stress Disorder in Mild Traumatic Brain Injury"],"prefix":"10.1177","volume":"36","author":[{"given":"Priya","family":"Santhanam","sequence":"first","affiliation":[{"name":"Lovelace Respiratory Research Institute, Albuquerque, New Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Teslovich","sequence":"additional","affiliation":[{"name":"Excentium, Inc., in support of National Intrepid Center of Excellence, Bethesda, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffanie H.","family":"Wilson","sequence":"additional","affiliation":[{"name":"The Emmes Corporation, Rockville, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Hong","family":"Yeh","sequence":"additional","affiliation":[{"name":"Northtide, in support of National Intrepid Center of Excellence, Bethesda, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrence R.","family":"Oakes","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindell K.","family":"Weaver","sequence":"additional","affiliation":[{"name":"Division of Hyperbaric Medicine, Intermountain Medical Center, Murray, Utah, and Intermountain LDS Hospital, Salt Lake City, Utah."},{"name":"Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,3,20]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Defense and Veterans Brain Injury Center. 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