{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:36:26Z","timestamp":1777926986437,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:00:00Z","timestamp":1555027200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>\n                    Following spinal cord injury (SCI), inflammation amplifies damage beyond the initial insult, providing an opportunity for targeted treatments. An ideal protective therapy would reduce both edema within the lesion area and the activation\/infiltration of detrimental immune cells. Previous investigations demonstrated the efficacy of intravenous injection of multipotent adult progenitor cells (MAPC\n                    <jats:sup>\u00ae<\/jats:sup>\n                    ) to modulate immune response following SCI, leading to significant improvements in tissue sparing, locomotor and urological functions. Separate studies have demonstrated that tissue inhibitor of matrix metalloproteinase-3 (TIMP3) reduces blood\u2013brain barrier permeability following traumatic brain injury in a mouse model, leading to improved functional recovery. This study examined whether TIMP3, delivered alone or in concert with MAPC cells, improves functional recovery from a contusion SCI in a rat model. The results suggest that intravenous delivery of MAPC cell therapy 1 day following acute SCI significantly improves tissue sparing and impacts functional recovery. TIMP3 treatment provided no significant benefit, and further, when co-administered with MAPC cells, it abrogated the therapeutic effects of MAPC cell therapy. Importantly, this study demonstrated for the first time that acute treatment of SCI with MAPC cells can significantly reduce the incidence of urinary tract infection (UTI) and the use of antibiotics for UTI treatment.\n                  <\/jats:p>","DOI":"10.1089\/neu.2018.5727","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T08:46:12Z","timestamp":1537865172000},"page":"1416-1427","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Multipotent Adult Progenitor Cells, but Not Tissue Inhibitor of Matrix Metalloproteinase-3, Increase Tissue Sparing and Reduce Urological Complications following Spinal Cord Injury"],"prefix":"10.1177","volume":"36","author":[{"given":"James M.","family":"Jones","sequence":"first","affiliation":[{"name":"Center for Regenerative Medicine, Oregon Health and Science University, Portland, Oregon."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc A.","family":"DePaul","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia R.","family":"Gregory","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, Oregon Health and Science University, Portland, Oregon."},{"name":"Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley T.","family":"Lang","sequence":"additional","affiliation":[{"name":"Athersys Inc., Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Xie","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, Oregon Health and Science University, Portland, Oregon."},{"name":"Department of Surgery, Oregon Health and Science University, Portland, Oregon."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, Oregon Health and Science University, Portland, Oregon."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Rutten","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, Oregon Health and Science University, Portland, Oregon."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Mays","sequence":"additional","affiliation":[{"name":"Athersys Inc., Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A.","family":"Busch","sequence":"additional","affiliation":[{"name":"Athersys Inc., Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shibani","family":"Pati","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of California San Francisco, San Francisco, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenton W.","family":"Gregory","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, Oregon Health and Science University, Portland, Oregon."},{"name":"Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,4,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1441-2772(23)02208-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2016.35"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3171\/FOC.2008.25.11.E2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1326"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00098"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3566-10.2011"},{"key":"e_1_3_3_8_2","first-page":"207","article-title":"Reduction of lesion in injured rat spinal cord and partial functional recovery of motility after bone marrow derived mesenchymal stem cell transplantation","volume":"22","author":"Karaoz E.","year":"2012","unstructured":"Karaoz E., , Kabatas S., , Duruksu G., , Okcu A., , Subasi C., , Ay B., , Musluman M., , and Civelek E. 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