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The current study sought to examine the neurological cause of this chronic dysfunction by testing the hypothesis that blast exposure leads to impaired filtering of sensory information at brainstem and early cortical levels. Groups of blast-exposed and non-blast-exposed participants completed self-report measures of auditory and neurobehavioral status, auditory perceptual tasks involving degraded and competing speech stimuli, and physiological measures of sensory gating, including pre-pulse inhibition and habituation of the acoustic startle reflex and electrophysiological assessment of a paired-click sensory gating paradigm. Blast-exposed participants showed significantly reduced habituation to acoustic startle stimuli and impaired filtering of redundant sensory information at the level the auditory cortex. Multiple linear regression analyses revealed that poorer sensory gating at the cortical level was primarily influenced by a diagnosis of TBI, whereas reduced habituation was primarily influenced by a diagnosis of post-traumatic stress disorder. A statistical model was created including cortical sensory gating and habituation to acoustic startle, which strongly predicted performance on a degraded speech task. These results support the hypothesis that blast exposure impairs central auditory processing via impairment of neural mechanisms underlying habituation and sensory gating.<\/jats:p>","DOI":"10.1089\/neu.2018.5801","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T09:03:07Z","timestamp":1534410187000},"page":"702-712","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Blast Exposure Impairs Sensory Gating: Evidence from Measures of Acoustic Startle and Auditory Event-Related Potentials"],"prefix":"10.1177","volume":"36","author":[{"given":"Melissa A.","family":"Papesh","sequence":"first","affiliation":[{"name":"National Center for Rehabilitative Auditory Research"},{"name":"Oregon Health & Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan E.","family":"Elliott","sequence":"additional","affiliation":[{"name":"National Center for Rehabilitative Auditory Research"},{"name":"Oregon Health & Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan L.","family":"Callahan","sequence":"additional","affiliation":[{"name":"National Center for Rehabilitative Auditory Research"},{"name":"Oregon Health & Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Storzbach","sequence":"additional","affiliation":[{"name":"National Center for Rehabilitative Auditory Research"},{"name":"Oregon Health & Science University"},{"name":"Oregon Health & Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda M.","family":"Lim","sequence":"additional","affiliation":[{"name":"National Center for Rehabilitative Auditory Research"},{"name":"Oregon Health & Science University"},{"name":"Oregon Health & Science University"},{"name":"Oregon Health & Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick J.","family":"Gallun","sequence":"additional","affiliation":[{"name":"National Center for Rehabilitative Auditory Research"},{"name":"Oregon Health & Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,2,22]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Defense and Veterans Brain Injury Center (2018). 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