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Low-field magnetic stimulation (LFMS) is a new noninvasive repetitive transcranial magnetic stimulation (rTMS) technique that generates diffused and low-intensity magnetic stimulation to deep cortical and subcortical areas. The role of LFMS on PrPc, proteins related to the circadian rhythm, and behavior alterations in a repeated TBI mouse model were studied in the present study. TBI was induced to the mice (right hemisphere) using weight-drop method, once daily for 3 days. LFMS treatment was given for 20\u2009min once daily for 4 days (immediately after each TBI induction). The results showed that LFMS-treated TBI mice significantly improved cognitive and motor function as evidenced by open field exploration, rotarod, and novel location recognition tasks. In addition, a significant increase in PrPc and decreased glial fibrillary acidic protein levels were observed in cortical and hippocampal regions of LFMS-treated TBI mice brain compared with sham-treated TBI mice, while neuronal nuclei level was significantly increased in cortical region. In LFMS-treated mice, a decrease in proteins related to circadian rhythm were observed, compared with sham-treated TBI mice. The results obtained from the study demonstrated the neuroprotective effect of LFMS, which may be through regulating PrPc and\/or proteins related to circadian rhythm. Thus, the present study suggests that LFMS may improve the subject's neurological condition following TBI.<\/jats:p>","DOI":"10.1089\/neu.2018.5918","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T07:25:56Z","timestamp":1556177156000},"page":"3103-3114","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Low-Field Magnetic Stimulation Restores Cognitive and Motor Functions in the Mouse Model of Repeated Traumatic Brain Injury: Role of Cellular Prion Protein"],"prefix":"10.1177","volume":"36","author":[{"given":"Sathiya","family":"Sekar","sequence":"first","affiliation":[{"name":"Department of Anatomy, Physiology, Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajar","family":"Miranzadeh Mahabadi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology, Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhassan","family":"Parvizi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology, Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changiz","family":"Taghibiglou","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology, Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.069583"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2015-0017"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1007051"},{"key":"e_1_3_3_5_2","article-title":"Chronic traumatic encephalopathy in contact sports: a systematic review of all reported pathological cases","volume":"10","author":"Maroon J.C.","year":"2015","unstructured":"Maroon J.C., , Winkelman R., , Bost J., , Amos A., , Mathyssek C., , and Miele V. 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