{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:54:41Z","timestamp":1783468481079,"version":"3.55.0"},"reference-count":77,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>\n                    Traumatic brain injury (TBI) has been identified as a risk factor for Alzheimer's disease (AD). However, how such neural damage contributes to AD pathology remains unclear; specifically, the relationship between the timing of a TBI relative to aging and the onset of AD pathology is not known. In this study, we have examined the effect of TBI on subsequent beta-amyloid (A\u03b2) deposition in APP\/PS1 (APP\n                    <jats:sub>SWE<\/jats:sub>\n                    \/PSEN1dE9) transgenic mice either before (3 months of age) or after the onset (6 months of age) of plaque pathology. Lateral fluid percussion injury (LFPI), a model of diffuse brain injury, was induced in APP\/PS1 and C57Bl\/6 wild-type (WT) littermates. LFPI caused a significant increase in both total (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and fibrillar (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) A\u03b2 plaque load in the cortex of 3-month-old APP\/PS1 mice compared to sham-treated mice at 30 days post-injury. However, in the cortex of 6-month-old mice at 30 days post-injury, LFPI caused a significant decrease in total (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.01), but not fibrillar (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&gt;\u20090.05), A\u03b2 plaque load compared to sham-treated mice. No A\u03b2 plaques were present in any WT mice across these conditions. Glial fibrillary acidic protein immunolabeling of astrocytes and ionized calcium-binding adapter molecule 1 immunolabeling of microglial\/macrophages was not significantly different (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05) in injured animals compared to sham mice, or APP\/PS1 mice compared to WT mice. The current data indicate that TBI may have differential effects on A\u03b2 plaque deposition depending on the age and the stage of amyloidosis at the time of injury.\n                  <\/jats:p>","DOI":"10.1089\/neu.2018.5982","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T05:58:27Z","timestamp":1547013507000},"page":"1876-1889","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Age Moderates the Effects of Traumatic Brain Injury on Beta-Amyloid Plaque Load in APP\/PS1 Mice"],"prefix":"10.1177","volume":"36","author":[{"given":"Jessica M.","family":"Collins","sequence":"first","affiliation":[{"name":"Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Tasmania, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"King","sequence":"additional","affiliation":[{"name":"Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Tasmania, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Woodhouse","sequence":"additional","affiliation":[{"name":"Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Tasmania, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.K.","family":"Kirkcaldie","sequence":"additional","affiliation":[{"name":"Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Tasmania, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Vickers","sequence":"additional","affiliation":[{"name":"Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Tasmania, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-014-0319-5"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.7.857"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/20.Supplement_2.S28"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700049588"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181a9d503"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1928.02700150029009"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92724-G"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.4.419"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12532"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2011.00513.x"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002413"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.11.010"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.4668"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.02.034"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3407"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-02-00446.2002"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990830)411:3<390::AID-CNE3>3.0.CO;2-#"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7375"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9578-3"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0858-11.2011"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025475"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.06.066"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0687-z"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1988.5.1"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1995.12.169"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2012.2630"},{"key":"e_1_3_4_28_2","first-page":"3063","article-title":"Lateral fluid percussion: model of traumatic brain injury in mice","volume":"22","author":"Alder J.","year":"2011","unstructured":"Alder J., , Fujioka W., , Lifshitz J., , Crockett D.P., , and Thakker-Varia S. 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