{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:37:06Z","timestamp":1777927026240,"version":"3.51.4"},"reference-count":55,"publisher":"SAGE Publications","issue":"18","license":[{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>\n                    Spinal cord injury (SCI) results in rapid muscle atrophy and an oxidative-to-glycolytic fiber-type shift. Those with chronic SCI are more at risk for developing insulin resistance and reductions in glucose clearance than able-bodied individuals, but how glucose metabolism is affected after SCI is not well known. An untargeted metabolomics approach was utilized to investigate changes in whole-muscle metabolites at an acute (7-day) and subacute (28-day) time frame after a complete T9 spinal cord transection in 20-week-old female C57BL\/6 mice. Two hundred one metabolites were detected in all samples, and 83 had BinBase IDs. A principal components analysis showed the 7-day group as a unique cluster. Further, 36 metabolites were altered after 7- and\/or 28-day post-SCI (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    values &lt;0.05), with 12 passing further false discovery rate exclusion criteria; of those 12 metabolites, three important glycolytic molecules\u2014glucose and downstream metabolites pyruvic acid and lactic acid\u2014were reduced at 7 days compared to those values in sham and\/or 28-day animals. These changes were associated with altered expression of proteins associated with glycolysis, as well as monocarboxylate transporter 4 gene expression. Taken together, our data suggest an acute disruption of skeletal muscle glucose uptake at 7 days post-SCI, which leads to reduced pyruvate and lactate levels. These levels recover by 28 days post-SCI, but a reduction in pyruvate dehydrogenase protein expression at 28 days post-SCI implies disruption in downstream oxidation of glucose.\n                  <\/jats:p>","DOI":"10.1089\/neu.2018.6144","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T10:11:59Z","timestamp":1552558319000},"page":"2722-2731","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Key Glycolytic Metabolites in Paralyzed Skeletal Muscle Are Altered Seven Days after Spinal Cord Injury in Mice"],"prefix":"10.1177","volume":"36","author":[{"given":"Zachary A.","family":"Graham","sequence":"first","affiliation":[{"name":"National Center for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York."},{"name":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob A.","family":"Siedlik","sequence":"additional","affiliation":[{"name":"Creighton University, Omaha, Nebraska."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Harlow","sequence":"additional","affiliation":[{"name":"National Center for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Sahbani","sequence":"additional","affiliation":[{"name":"National Center for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Bauman","sequence":"additional","affiliation":[{"name":"National Center for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York."},{"name":"Medical Service, James J. Peters VA Medical Center, Bronx, New York."},{"name":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York."},{"name":"Department of Rehabilitation Medicine and Human Performance, Icahn School of Medicine at Mount Sinai, New York, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesham A.","family":"Tawfeek","sequence":"additional","affiliation":[{"name":"National Center for the Medical Consequences of Spinal Cord Injury, James J. 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