{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:21:24Z","timestamp":1782789684883,"version":"3.54.5"},"reference-count":43,"publisher":"SAGE Publications","issue":"17","license":[{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>\n                    Our objective was to examine associations of head injury with total and regional brain amyloid deposition. We performed cross-sectional analyses of 329 non-demented participants (81 with prior head injury) in the Atherosclerosis Risk in Communities-Positron Emission Tomography (ARIC-PET) Study who underwent\n                    <jats:sup>18-<\/jats:sup>\n                    florbetapir PET imaging in 2012\u20132014. A history of head injury was defined by self-report or emergency department\/hospitalization International Classification of Diseases, Ninth Revision codes. Generalized linear regression models adjusted for demographic, socioeconomic, and dementia\/cardiovascular risk factors were used to estimate prevalence ratios (PRs; 95% confidence intervals [CIs]) for elevated (&gt; 1.2) global and regional standard uptake value ratios (SUVRs). Mean age of participants was 76 years, 57% were women, and 43% were black. Head injury was associated with increased prevalence of elevated SUVR &gt;1.2 globally (PR: 1.31; 95% CI: 1.19\u20131.57), as well as in the orbitofrontal cortex (PR: 1.23); (95% CI: 1.04\u20131.46), prefrontal cortex (PR: 1.18; 95% CI: 1.00\u20131.39), superior frontal cortex (PR: 1.24; 95% CI: 1.05\u20131.48), and posterior cingulate (PR: 1.26; 95% CI: 1.04\u20131.52). There also was evidence for a dose\u2013response relationship, whereby a history of \u22651 head injury was associated with elevated SUVR &gt;1.2 in the prefrontal cortex and superior frontal cortex compared with persons with a history of one head injury (all,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In conclusion, head injury was associated with increased amyloid deposition globally and in the frontal cortex and posterior cingulate, with suggestion of a dose\u2013response association of head injuries with beta-amyloid deposition. Further work is needed to determine if increased amyloid deposition contributes to dementia in this population.\n                  <\/jats:p>","DOI":"10.1089\/neu.2018.6213","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T07:49:30Z","timestamp":1554796170000},"page":"2549-2557","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Association of Head Injury with Brain Amyloid Deposition: The ARIC-PET Study"],"prefix":"10.1177","volume":"36","author":[{"given":"Andrea L.C.","family":"Schneider","sequence":"first","affiliation":[{"name":"Department of Neurology, Johns Hopkins University, Baltimore, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Selvin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglu","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Latour","sequence":"additional","affiliation":[{"name":"National Institute of Neurological Disorders and Stroke, Bethesda, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Christine","family":"Turtzo","sequence":"additional","affiliation":[{"name":"National Institute of Neurological Disorders and Stroke, Bethesda, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Koton","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland."},{"name":"Department of Nursing, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Coresh","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Mosley","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Whitlow","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina."},{"name":"Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina."},{"name":"Department of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, North Carolina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean F.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Radiology, Johns Hopkins University, Baltimore, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University, Baltimore, Maryland."},{"name":"Department of Neurology, Uniformed Services University, Bethesda, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca F.","family":"Gottesman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University, Baltimore, Maryland."},{"name":"Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,8,20]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.22"},{"key":"e_1_3_4_3_2","volume-title":"Report to Congress on Traumatic Brain Injury in the United States: Epidemiology and Rehabilitation","author":"Centers for Disease Control and Prevention","year":"2015","unstructured":"Centers for Disease Control and Prevention (2015). 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(2017). Effects of traumatic brain injury and posttraumatic stress disorder on development of Alzheimer's disease in Vietnam Veterans using the Alzheimer's Disease Neuroimaging Initiative: preliminary report. Alzheimers Dement. (N. Y.) 3, 177\u2013188.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115184"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007847"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000165985.97397.88"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002914"},{"key":"e_1_3_4_30_2","first-page":"1","article-title":"Mild Cognitive Impairment and Dementia Prevalence: the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)","volume":"2","author":"Knopman D.S.","year":"2016","unstructured":"Knopman D.S., , Gottesman R.F., , Sharrett A.R., , Wruck L.M., , Windham B.G., , Coker L., , Schneider A.L., , Hengrui S., , Alonso A., , Coresh J., , Albert M.S., , and Mosley T.H. Jr. (2016). Mild Cognitive Impairment and Dementia Prevalence: the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS). 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