{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:46:55Z","timestamp":1793209615781,"version":"4.5.0"},"reference-count":53,"publisher":"SAGE Publications","issue":"21","license":[{"start":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T00:00:00Z","timestamp":1570579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>\n                    The present study was designed to evaluate the therapeutic effectiveness and mechanism of acute intermittent hypoxia on respiratory function at distinct injury stages following mid-cervical spinal contusion. In the first experiment, adult male rats received laminectomy or unilateral contusion at 3rd-4th cervical spinal cord at 9 weeks of age. The ventilatory behavior in response to mild acute intermittent hypercapnic-hypoxia (10 episodes of 5\u2009min of hypoxia [10% O\n                    <jats:sub>2<\/jats:sub>\n                    , 4% CO\n                    <jats:sub>2<\/jats:sub>\n                    , 86% N\n                    <jats:sub>2<\/jats:sub>\n                    ] with 5\u2009min of normoxia intervals) was measured by whole\u2013body plethysmography at the acute (\u223c3 days), subchronic (\u223c2 weeks), and chronic (\u223c8 weeks) injury stages. The minute ventilation of contused animals is significantly enhanced following acute intermittent hypercapnic-hypoxia due to an augmentation of the tidal volume at all time-points post-injury. However, acute intermittent hypercapnia-hypoxia\u2013induced ventilatory long-term facilitation was only observed in uninjured animals at the acute stage. During the second experiment, the effect of acute intermittent hypercapnic-hypoxia on respiration was examined in contused animals after a blockade of serotonin receptors, or adenosine 2A receptors. The results demonstrated that acute intermittent hypercapnic-hypoxia\u2013induced enhancement of minute ventilation was attenuated by a serotonin receptor antagonist (methysergide) but enhanced by an adenosine 2A receptor antagonist (KW6002) at the subchronic and chronic injury stages. These results suggested that acute intermittent hypercapnic-hypoxia can induce respiratory recovery from acute to chronic injury stages. The therapeutic effectiveness of intermittent hypercapnic-hypoxia is dampened by the inhibition of serotonin receptors, but a blockade of adenosine 2A receptors enhanced respiratory recovery induced by intermittent hypercapnic-hypoxia.\n                  <\/jats:p>","DOI":"10.1089\/neu.2018.6371","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T05:16:50Z","timestamp":1558070210000},"page":"2991-3004","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Modulation of Serotonin and Adenosine 2A Receptors on Intermittent Hypoxia-Induced Respiratory Recovery following Mid-Cervical Contusion in the Rat"],"prefix":"10.1177","volume":"36","author":[{"given":"Ming-Han","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Jane","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Vinit","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines, INSERM U1179 END-ICAP, UFR des Sciences de la Sant\u00e9-Simone Veil, Montigny-le-Bretonneux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Ze","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan."},{"name":"Center for Neuroscience, National Sun Yat-sen University, Kaohsiung, Taiwan."},{"name":"Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan."},{"name":"Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan."},{"name":"Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2018.04.005"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.5798"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2018.03.014"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5128"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.08.007"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.08.018"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.23.1137"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00088.2015"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201305-0848OC"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.01.035"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0148-05.2005"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3393"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968316680494"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1166"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.5.2001"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00235.2015"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00463.2003"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2017.05.004"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.03.026"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.02.007"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP270818"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4645"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01001.2013"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(80)90064-X"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00896.2005"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.236109"},{"key":"e_1_3_3_28_2","first-page":"58","article-title":"The impact of intermittent or sustained carbon dioxide on intermittent hypoxia initiated respiratory plasticity","volume":"256","author":"Mateika J.H.","year":"2018","unstructured":"Mateika J.H., , Panza G., , Alex R., , and El-Chami M. 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