{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:38:01Z","timestamp":1777927081718,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>\n                    Variability in recovery among concussed athletes can be attributed to several risk factors. One risk factor not definitively explored is genetic variation. Genetic variations such as variable number tandem repeats (VNTR) in the promotor region are normal in the population, and can lead to disparities in the amount of protein produced, which could be associated with neuronal recovery. Little research has been conducted to investigate promoter VNTRs within genes responsible for recovery following a concussion. The authors implemented a prospective cohort design using a standardized concussion protocol to diagnose and follow 93 athletes to full recovery at three different sites to determine the association between promotor GT(n) VNTR polymorphisms and recovery time within concussed athletes. The GT(n) VNTR within the promoter region of glutamate ionotropic receptor\n                    <jats:italic toggle=\"yes\">N-<\/jats:italic>\n                    methyl-d-aspartate (NMDA) type subunit 2A (\n                    <jats:italic toggle=\"yes\">GRIN2A<\/jats:italic>\n                    ), potassium voltage-gated channel subfamily H member 2 (\n                    <jats:italic toggle=\"yes\">KCNH2<\/jats:italic>\n                    ), glutamate ionotropic receptor kainate type subunit 1 (\n                    <jats:italic toggle=\"yes\">GRIK1<\/jats:italic>\n                    ), and neurofilament light (\n                    <jats:italic toggle=\"yes\">NEFL<\/jats:italic>\n                    ) were genotyped using capillary electrophoresis. GT(n) VNTR promotor polymorphisms were dichotomized into long (L) and short (s) alleles. Using adjusted negative binomial regression models we found that athletes carrying the LL\n                    <jats:italic toggle=\"yes\">GRIN2A<\/jats:italic>\n                    GT(n) VNTR within the promoter region were more likely to experience a prolonged concussion recovery, which resulted in their not being able to return to play for \u223c60 days. Additionally, there was a trend toward significance, in which the ss\n                    <jats:italic toggle=\"yes\">NEFL<\/jats:italic>\n                    GT(n) Caucasian athletes had prolonged concussion recovery. This could presumably be attributed to altered proteins or protein levels that disrupt neuronal recovery. This pilot study suggests that these VNTRs are associated with prolonged concussion recovery. In future studies, we plan to measure the extent to which the L or s alleles alter the level and the activity of the GluNR2a and NEFL proteins that\n                    <jats:italic toggle=\"yes\">GRIN2A<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">NEFL<\/jats:italic>\n                    produce, respectively.\n                  <\/jats:p>","DOI":"10.1089\/neu.2019.6590","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T02:59:37Z","timestamp":1576637977000},"page":"1204-1210","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between (GT)n Promoter Polymorphism and Recovery from Concussion: A Pilot Study"],"prefix":"10.1177","volume":"37","author":[{"given":"Jane","family":"McDevitt","sequence":"first","affiliation":[{"name":"Department of Kinesiology, Temple University, Philadelphia, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah H.","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca I.","family":"De Simone","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaqueline","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Temple University, Philadelphia, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne","family":"Langford","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511410655"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2017-097699"},{"key":"e_1_3_4_4_2","article-title":"Concussion burden, recovery, and risk factors in elite youth ice hockey players","author":"Schneider K.J.","year":"2018","unstructured":"Schneider K.J., , Nettel-Aguirre A., , Palacios-Derflingher L., , Mrazik M., , Brooks B.L., , Woollings K., , Blake T., , McKay C., , Lebrun C., , Barlow K., , Taylor K., , Lemke N., , Meeuwisse W.H., , and Emery C.A. 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