{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:19:44Z","timestamp":1788920384917,"version":"build-2803163510"},"reference-count":41,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Both clinical and experimental studies have reported that mild traumatic brain injury (mTBI) can result in cognitive impairments in the absence of overt brain damage. Whether these impairments result from neuronal dysfunction\/altered plasticity is an area that has received limited attention. In this study, we recorded activity of neurons in the cornu Ammonis (CA)1 subfield of the hippocampus in sham and mild lateral fluid percussion injured (mFPI) rats while these animals were performing an object location task. Electrophysiology results showed that the number of excitatory neurons encoding spatial information (i.e., place cells) was reduced in mFPI rats, and that these cells had broader and less stable place fields. Additionally, the in-field firing rate of place cells in sham operated, but not in mFPI, animals increased when objects within the testing arena were moved. Immunostaining indicated no visible damage or overall neuronal loss in mFPI brain sections. However, a reduction in the number of parvalbumin-positive inhibitory neurons in the CA1 subfield of mFPI animals was observed, suggesting that this reduction could have influenced place cell physiology. Alterations in spatial information content, place cell stability, and activity in mFPI rats coincided with poor performance in the object location task. These results indicate that altered place cell physiology may underlie the hippocampus-dependent cognitive impairments that result from mTBI.<\/jats:p>","DOI":"10.1089\/neu.2019.6766","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T07:28:50Z","timestamp":1568791730000},"page":"227-235","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Mild Traumatic Brain Injury Decreases Spatial Information Content and Reduces Place Field Stability of Hippocampal CA1 Neurons"],"prefix":"10.1177","volume":"37","author":[{"given":"John I.","family":"Broussard","sequence":"first","affiliation":[{"name":"Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Redell","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Maynard","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhide","family":"Kobori","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly N.","family":"Hood","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu O.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony N.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod K.","family":"Dash","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)91104-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4107"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.2192"},{"key":"e_1_3_3_5_2","first-page":"171","article-title":"The hippocampus as a spatial map","volume":"34","author":"O'Keefe J.","year":"1971","unstructured":"O'Keefe J., , and Dostrovsky J. (1971). The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Res. 34, 171\u2013175.","journal-title":"Preliminary evidence from unit activity in the freely-moving rat. Brain Res"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.1.105"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4653"},{"key":"e_1_3_3_8_2","volume-title":"Proceeding Advances in Neural Information Processing Systems","author":"Skaggs W.E.","year":"1993","unstructured":"Skaggs W.E., , McNaughton B.L., , Gothard K., , and Markus E.J. (1993). An information-theoretical approach to deciphering the hippocampal code, in: Proceeding Advances in Neural Information Processing Systems, Morgan Kaufmann, San Francisco, CA, pps. 1030\u20131037."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1825"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00731.2007"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3130-14.2015"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.06.032"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81904-2"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1987.67.1.0110"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1994.11.289"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.07.014"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1370"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1088\/0954-898X_9_4_001"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.10.003"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-01-00274.1999"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.1.390"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-07-01935.1987"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-12-07347.1994"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature00807"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6413-10.2011"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3077"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4486"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22268"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00614.2003"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphysparis.2011.09.002"},{"key":"e_1_3_3_31_2","article-title":"Allocentric representations of space in the hippocampus","author":"Danjo T.","year":"2019","unstructured":"Danjo T. (2019). Allocentric representations of space in the hippocampus. Neurosci. Res. [Epub ahead of print].","journal-title":"Neurosci. Res"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.450030307"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-23-08853.2000"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-12-04846.1992"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22803"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht198"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5372.2121"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.03.011"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90254-9"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.01.070"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)02069-1"},{"issue":"14","key":"e_1_3_3_42_2","first-page":"835","article-title":"Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory","volume":"113","author":"Kempadoo K.A.","year":"2016","unstructured":"Kempadoo K.A., , Mosharov E.V., , Choi S.J., , Sulzer D., , and Kandel E.R. (2016). Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory. Proc. Natl. Acad. Sci. U. S. A, 113, 14, 835\u201314,840.","journal-title":"Proc. Natl. Acad. Sci. U. S. A"}],"container-title":["Journal of Neurotrauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/neu.2019.6766","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2019.6766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2019.6766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:35:16Z","timestamp":1777674916000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/neu.2019.6766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,20]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1089\/neu.2019.6766"],"URL":"https:\/\/doi.org\/10.1089\/neu.2019.6766","relation":{},"ISSN":["0897-7151","1557-9042"],"issn-type":[{"value":"0897-7151","type":"print"},{"value":"1557-9042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,20]]}}}