{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:00:27Z","timestamp":1790697627053,"version":"4.1.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>\n                    We prospectively evaluated serum concentrations of glial fibrillary acidic protein (GFAP), ubiquitin c-terminal hydrolase L1 (UCH-L1), total tau (T-Tau), and neurofilament light (NF-L) from collegiate athletes at baseline and acutely after sport-related concussion (SRC) using the Quanterix Neurology 4Plex \u201cB\u201d (N4PB) multiplex assay. Uninjured controls were matched on age, sex, race, sport, and concussion history. Clinical outcomes included acute symptom severity, balance, rapid automated naming, computerized cognitive testing, and recovery duration. Baseline (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u2009110; median [interquartile range] age\u2009=\u200919 [18\u201320] years, 54% male, 61% white\/Caucasian) and post-SRC (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200936; median [interquartile range] age\u2009=\u200919 [18\u201320] years, 50% male, 61% white\/Caucasian) blood samples were analyzed. We observed post-SRC elevations from baseline for GFAP (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.001,\n                    <jats:italic toggle=\"yes\">d<\/jats:italic>\n                    \u2009=\u20091.7), T-Tau (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.004,\n                    <jats:italic toggle=\"yes\">d<\/jats:italic>\n                    \u2009=\u20091.3), and NF-L (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.010,\n                    <jats:italic toggle=\"yes\">d<\/jats:italic>\n                    \u2009=\u20091.1). GFAP (area under the curve [AUC]\u2009=\u20090.958, 95% confidence interval [CI] 0.927\u20130.989,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and NF-L (AUC\u2009=\u20090.904, 95% CI 0.851\u20130.957,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) accurately discriminated SRC from control cases. There were no associations between biomarker concentrations and clinical measurements post-SRC or recovery duration. These findings suggest that, using the multiplex assay, GFAP, T-Tau, and NF-L elevate from baseline acutely after SRC, and both GFAP and NF-L excellently distinguished concussed from control cases. Serum biomarker changes do not necessarily correspond with clinical measurements or recovery duration.\n                  <\/jats:p>","DOI":"10.1089\/neu.2019.6831","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T01:52:57Z","timestamp":1580953977000},"page":"1537-1545","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Acute Effects of Sport-Related Concussion on Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase L1, Total Tau, and Neurofilament Light Measured by a Multiplex Assay"],"prefix":"10.1177","volume":"37","author":[{"given":"Breton M.","family":"Asken","sequence":"first","affiliation":[{"name":"Department of Neurology, University of California, San Francisco, California, USA."},{"name":"Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Florida, Gainesville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Florida, Gainesville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur G.","family":"Weber","sequence":"additional","affiliation":[{"name":"Banyan Biomarkers, Inc., San Diego, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald L.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Banyan Biomarkers, Inc., San Diego, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell M.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven T.","family":"DeKosky","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Florida, Gainesville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Jaffee","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Florida, Gainesville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin K.W.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Florida, Gainesville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Clugston","sequence":"additional","affiliation":[{"name":"Department of Community Health and Family Medicine, University of Florida, Gainesville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"crossref","unstructured":"McCrea M. 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