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Whether the time course of neurodegeneration, locomotor impairment, or neuropathic pain varies with sex, however, remains understudied. Therefore, the objective of this study in male and female C57BL\/6 mice was to evaluate the following outcomes for six weeks after a 75-kdyn thoracic contusion SCI: locomotor function using the Basso Mouse Scale (BMS); spinal cord tissue sparing and rostral-caudal lesion length; and mechanical allodynia and heat hyperalgesia using hindpaw application of Von Frey filaments or radiant heat stimuli, respectively. Although motor function was largely similar between sexes, all of the males, but only half of the females, recovered plantar stepping. Rostral-caudal lesion length was shorter in females than in males. Mechanical allodynia and heat hyperalgesia after SCI developed in all animals, regardless of sex; there were no differences in pain outcomes between sexes. We conclude that contusion SCI yields subtle sex differences in mice depending on the outcome measure but no significant differences in behavioral signs of neuropathic pain.<\/jats:p>","DOI":"10.1089\/neu.2019.6931","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T06:18:20Z","timestamp":1593238700000},"page":"1983-1990","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":46,"title":["Effect of Sex on Motor Function, Lesion Size, and Neuropathic Pain after Contusion Spinal Cord Injury in Mice"],"prefix":"10.1177","volume":"37","author":[{"given":"Katelyn","family":"McFarlane","sequence":"first","affiliation":[{"name":"Spinal Cord and Brain Injury Research Center and Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor E.","family":"Otto","sequence":"additional","affiliation":[{"name":"Spinal Cord and Brain Injury Research Center and Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Spinal Cord and Brain Injury Research Center and Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy K.","family":"Veldhorst","sequence":"additional","affiliation":[{"name":"Spinal Cord and Brain Injury Research Center and Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e R.","family":"Donahue","sequence":"additional","affiliation":[{"name":"Spinal Cord and Brain Injury Research Center and Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley K.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Medicine, Pittsburgh Center for Pain Research, and Pittsburgh Project to End Opioid Misuse, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Gensel","sequence":"additional","affiliation":[{"name":"Spinal Cord and Brain Injury Research Center and Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2015.167"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/509282a"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2018.03.006"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.165213"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3702"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2008.04.0053"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101407"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.05.011"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.04.053"},{"key":"e_1_3_5_11_2","doi-asserted-by":"crossref","unstructured":"Scheff S.W. 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