{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:38:58Z","timestamp":1777927138096,"version":"3.51.4"},"reference-count":67,"publisher":"SAGE Publications","issue":"23","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>\n                    Chronic symptoms after mild traumatic brain injury (mTBI) are common among veterans and service members, and represent a significant source of morbidity, with those who sustain multiple mTBIs at greatest risk. Exosomal micro-RNAs (miRNAs), mediators of intercellular communication, may be involved in chronic TBI symptom persistence. Exosomal miRNA (exomiR) was extracted from 153 participants enrolled in the Chronic Effect of Neurotrauma Consortium (CENC) longitudinal study (no TBI,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200935; \u2265 3 mTBIs (rTBI),\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200945; 1\u20132 mTBIs,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200973). Analyses were performed with nCounter\n                    <jats:sup>\u00ae<\/jats:sup>\n                    Human miRNA Expression Panels and Ingenuity Pathway Analysis (IPA) for identification of gene networks associated with TBI. Generalized linear models were used to analyze the predictive value of exomiR dysregulation and remote neurobehavioral symptoms. Compared with controls, there were 17 dysregulated exomiRs in the entire mTBI group and 32 dysregulated exomiRs in the rTBI group. Two miRNAs, hsa-miR-139-5p and hsa-miR-18a-5p, were significantly differentially expressed in the rTBI and 1\u20132 mTBI groups. IPA analyses showed that these dysregulated exomiRs correlated with pathways of inflammatory regulation, neurological disease, and cell development. Within the rTBI group, exomiRs correlated with gene activity for hub-genes of tumor protein TP53, insulin-like growth factor 1 receptor, and transforming growth factor beta. TBI history and neurobehavioral symptom survey scores negatively and significantly correlated with hsa-miR-103a-3p expression. Participants with remote mTBI have distinct exomiR profiles, which are significantly linked to inflammatory and neuronal repair pathways. These profiles suggest that analysis of exosomal miRNA expression may provide novel insights into the underlying pathobiology of chronic TBI symptom persistence.\n                  <\/jats:p>","DOI":"10.1089\/neu.2019.6933","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T06:00:51Z","timestamp":1590559251000},"page":"2482-2492","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":41,"title":["Exosomal MicroRNAs in Military Personnel with Mild Traumatic Brain Injury: Preliminary Results from the Chronic Effects of Neurotrauma Consortium Biomarker Discovery Project"],"prefix":"10.1177","volume":"37","author":[{"given":"Christina","family":"Devoto","sequence":"first","affiliation":[{"name":"Tissue Injury Branch, National Institutes of Nursing Research, National Institutes of Health, Bethesda, Maryland, USA."},{"name":"Center for Neuroscience and Rehabilitation Medicine, Uniformed Services University of the Health Sciences and National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Lai","sequence":"additional","affiliation":[{"name":"Tissue Injury Branch, National Institutes of Nursing Research, National Institutes of Health, Bethesda, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao-Xi","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Uniformed Services University of the Health Sciences and National Institutes of Health, Bethesda, Maryland, USA"},{"name":"CENC Biorepository, Uniformed Services University of the Health Sciences, Twinbrook, Rockville, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian A.","family":"Guedes","sequence":"additional","affiliation":[{"name":"Tissue Injury Branch, National Institutes of Nursing Research, National Institutes of Health, Bethesda, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Leete","sequence":"additional","affiliation":[{"name":"Tissue Injury Branch, National Institutes of Nursing Research, National Institutes of Health, Bethesda, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Wilde","sequence":"additional","affiliation":[{"name":"CENC Imaging Core, University of Utah, Salt Lake City, Utah, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, Virginia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon","family":"Diaz-Arrastia","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimbra","family":"Kenney","sequence":"additional","affiliation":[{"name":"Department of Neurology, Uniformed Services University of the Health Sciences and National Institutes of Health, Bethesda, Maryland, USA"},{"name":"CENC Biorepository, Uniformed Services University of the Health Sciences, Twinbrook, Rockville, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Gill","sequence":"additional","affiliation":[{"name":"Tissue Injury Branch, National Institutes of Nursing Research, National Institutes of Health, Bethesda, Maryland, USA."},{"name":"Center for Neuroscience and Rehabilitation Medicine, Uniformed Services University of the Health Sciences and National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.29"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2010.08.007"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4434"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.0143"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001758"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.04.012"},{"key":"e_1_3_5_8_2","first-page":"176","article-title":"Secondary injury after head trauma: subacute and long-term mechanisms","volume":"3","author":"DeKosky S.T.","year":"1998","unstructured":"DeKosky S.T., , Kochanek P.M., , Clark R.S., , Ciallella J.R., , and Dixon C.E. 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