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Among these variables are genetically determined individual differences, which can modulate TBI outcome through their influence on neuroplasticity mechanisms. In this study, we examined the effect of Val66Met, a common polymorphism of the brain-derived neurotrophic factor gene known to be involved in neuroplasticity mechanisms, on behavioral symptoms of mild TBI (mTBI) sustained in early childhood. This work is part of a prospective, longitudinal cohort study of early TBI. The current sample consisted of 145 children between ages 18 and 60 months assigned to one of three participant groups: mild TBI, orthopedic injury, or typically developing children. Participants provided a saliva sample to detect the presence of the Val66Met polymorphism, and the Child Behavior Checklist was used to document the presence of behavioral symptoms at 6- and 18-months post-injury. Contrary to our initial hypothesis, at 6 months post-injury, non-carriers of the Val66Met polymorphism in the mTBI group presented significantly more internalizing symptoms (e.g., anxiety\/depression and somatic complaints) than Val66Met carriers, who were similar to orthopedically injured and typically developing children. However, at 18 months post-injury, all children with mTBI presented more internalizing symptoms, independent of genotype. The results of the study provide evidence for a protective effect of the Val66Met polymorphism on internalizing behavior symptoms 6 months after early childhood mTBI.<\/jats:p>","DOI":"10.1089\/neu.2019.6936","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T01:22:30Z","timestamp":1593566550000},"page":"102-110","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Internalizing Behaviors after Early Mild Traumatic Brain Injury"],"prefix":"10.1177","volume":"38","author":[{"given":"Charlotte","family":"Gagner","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Montreal, Montr\u00e9al, Qu\u00e9bec, Canada."},{"name":"Sainte-Justine Hospital Research Center, Montr\u00e9al, Qu\u00e9bec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carola","family":"Tuerk","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Montreal, Montr\u00e9al, Qu\u00e9bec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"De Beaumont","sequence":"additional","affiliation":[{"name":"H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al Research Center, Montr\u00e9al, Qu\u00e9bec, Canada."},{"name":"Department of Surgery, University of Montreal, Montr\u00e9al, Qu\u00e9bec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Bernier","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Montreal, Montr\u00e9al, Qu\u00e9bec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam H.","family":"Beauchamp","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Montreal, Montr\u00e9al, Qu\u00e9bec, Canada."},{"name":"Sainte-Justine Hospital Research Center, Montr\u00e9al, Qu\u00e9bec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0015268"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/02699052.2013.812240"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1728"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2013.12.018"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.1203"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/02699052.2013.804205"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.2009.00947.x"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/09297049508400224"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717003221"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617704103093"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0018387"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1073858414543150"},{"key":"e_1_3_4_14_2","first-page":"S241","article-title":"Genetic factors modulating outcome after neurotrauma","volume":"2","author":"McAllister T.W.","year":"2010","unstructured":"McAllister T.W. 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