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Our study aimed to investigate the use of ultra-high-field diffusion tensor imaging (UHF-DTI) in discerning severity-dependent microstructural changes in the mouse brain following a concussion. Twenty-three C57BL\/6 mice were randomly allocated into three groups: the low concussive (LC,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20099) injury group, the high concussive (HC,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20096) injury group, and the sham control (SC,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20097) group. Mice were perfused on day 2 post-injury, and the brains were scanned on a 16.4T MRI scanner with UHF-DTI and neurite orientation dispersion imaging (NODDI). Finite element analysis (FEA) was performed to determine the pattern and extent of the physical impact on the brain tissue. MRI findings were correlated with histopathological analysis in a subset of mice. In the LC group, increased fractional anisotropy (FA) and decreased orientation dispersion index (ODI) but limited neurite density index (NDI) changes were found in the gray matter, and minimal changes to white matter (WM) were observed. The HC group presented increased mean diffusivity (MD), decreased NDI, and decreased ODI in the WM and gray matter (GM); decreased FA was also found in a small area of the WM. WM changes were associated with WM degeneration and neuroinflammation. FEA showed varying region-dependent degrees of stress, in line with the different imaging findings. This study provides evidence that UHF-DTI combined with NODDI can detect concussions of variable intensities. This has significant implications for the diagnosis of concussion in humans.\n                  <\/jats:p>","DOI":"10.1089\/neu.2019.6944","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T05:20:04Z","timestamp":1589260804000},"page":"967-982","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Ultra-High-Field Diffusion Tensor Imaging Identifies Discrete Patterns of Concussive Injury in the Rodent Brain"],"prefix":"10.1177","volume":"38","author":[{"given":"Xuan Vinh","family":"To","sequence":"first","affiliation":[{"name":"The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Benetatos","sequence":"additional","affiliation":[{"name":"The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, 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