{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:39:04Z","timestamp":1777927144768,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"23","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>\n                    Intracranial pressure (ICP) is an important parameter to monitor in several neuropathologies. However, because current clinically accepted methods are invasive, its monitoring is limited to patients in critical conditions. On the other hand, there are other less critical conditions for which ICP monitoring could still be useful; therefore, there is a need to develop non-invasive methods. We propose a new method to estimate ICP based on the analysis of the non-invasive measurement of pulsatile, microvascular cerebral blood flow with diffuse correlation spectroscopy. This is achieved by training a recurrent neural network using only the cerebral blood flow as the input. The method is validated using a 50% split sample method using the data from a proof-of-concept study. The study involved a population of infants (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20096) with external hydrocephalus (initially diagnosed as benign enlargement of subarachnoid spaces) as well as a population of adults (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20096) with traumatic brain injury. The algorithm was applied to each cohort individually to obtain a model and an ICP estimate. In both diverse cohorts, the non-invasive estimation of ICP was achieved with an accuracy of &lt;4\u2009mm Hg and a negligible small bias. Further, we have achieved a good correlation (Pearson's correlation coefficient &gt;0.9) and good concordance (Lin's concordance correlation coefficient &gt;0.9) in comparison with standard clinical, invasive ICP monitoring. This preliminary work paves the way for further investigations of this tool for the non-invasive, bedside assessment of ICP.\n                  <\/jats:p>","DOI":"10.1089\/neu.2019.6965","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T04:39:51Z","timestamp":1590640791000},"page":"2569-2579","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Non-Invasive Estimation of Intracranial Pressure by Diffuse Optics: A Proof-of-Concept Study"],"prefix":"10.1177","volume":"37","author":[{"given":"Jonas B.","family":"Fischer","sequence":"first","affiliation":[{"name":"ICFO-Institut de Ci\u00e8ncies Fot\u00f2niques, The Barcelona Institute of Science and Technology, Castelldefels, Barcelona, Spain."},{"name":"HemoPhotonics S.L., Castelldefels, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameer","family":"Ghouse","sequence":"additional","affiliation":[{"name":"ICFO-Institut de Ci\u00e8ncies Fot\u00f2niques, The Barcelona Institute of Science and Technology, Castelldefels, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Tagliabue","sequence":"additional","affiliation":[{"name":"ICFO-Institut de Ci\u00e8ncies Fot\u00f2niques, The Barcelona Institute of Science and Technology, Castelldefels, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Maruccia","sequence":"additional","affiliation":[{"name":"ICFO-Institut de Ci\u00e8ncies Fot\u00f2niques, The Barcelona Institute of Science and Technology, Castelldefels, Barcelona, Spain."},{"name":"Neurotraumatology and Neurosurgery Research Unit (UNINN), Vall d'Hebron Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rey-Perez","sequence":"additional","affiliation":[{"name":"Neurotrauma Intensive Care Unit, Vall d'Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelino","family":"B\u00e1guena","sequence":"additional","affiliation":[{"name":"Neurotrauma Intensive Care Unit, Vall d'Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Cano","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Vall d'Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Zucca","sequence":"additional","affiliation":[{"name":"Synthetic Perceptive, Emotive and Cognitive Systems (SPECS), Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udo M.","family":"Weigel","sequence":"additional","affiliation":[{"name":"HemoPhotonics S.L., Castelldefels, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Sahuquillo","sequence":"additional","affiliation":[{"name":"Neurotraumatology and Neurosurgery Research Unit (UNINN), Vall d'Hebron Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain."},{"name":"Department of Neurosurgery, Vall d'Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Poca","sequence":"additional","affiliation":[{"name":"Neurotraumatology and Neurosurgery Research Unit (UNINN), Vall d'Hebron Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain."},{"name":"Department of Neurosurgery, Vall d'Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turgut","family":"Durduran","sequence":"additional","affiliation":[{"name":"ICFO-Institut de Ci\u00e8ncies Fot\u00f2niques, The Barcelona Institute of Science and Technology, Castelldefels, Barcelona, Spain."},{"name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"e_1_3_5_2_2","article-title":"Intracranial pressure monitoring: invasive versus non-invasive methods \u2013 a review","author":"Raboel P.","year":"2012","unstructured":"Raboel P., , Bartek J., , Andresen M., , Bellander B., , and Romner B. 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