{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:34:14Z","timestamp":1781811254616,"version":"3.54.5"},"reference-count":78,"publisher":"SAGE Publications","issue":"21","license":[{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>Individuals with spinal cord injury (SCI) often develop debilitating neuropathic pain, which may be driven by neuronal damage and neuroinflammation. We have previously demonstrated that treatment using 670\u2009nm (red) light irradiation alters microglia\/macrophage responses and alleviates mechanical hypersensitivity at 7 days post-injury (dpi). Here, we investigated the effect of red light on the development of mechanical hypersensitivity, neuronal markers, and glial response in the subacute stage (days 1\u20137) following SCI.<\/jats:p>\n                  <jats:p>\n                    Wistar rats were subjected to a mild hemi-contusion SCI at vertebra T10 or to sham surgery followed by daily red-light treatment (30\u2009min\/day; 670\u2009nm LED; 35\u2009mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ) or sham treatment. Mechanical sensitivity of the rat dorsum was assessed from 1\u2009dpi and repeated every second day. Spinal cords were collected at 1, 3, 5, and 7\u2009dpi for analysis of myelination, neurofilament protein NF200 expression, neuronal cell death, reactive astrocytes (glial fibrillary acidic protein [GFAP]\n                    <jats:sup>+<\/jats:sup>\n                    cells), interleukin 1 \u03b2 (IL-1\u03b2) expression, and inducible nitric oxide synthase (iNOS) production in IBA1\n                    <jats:sup>+<\/jats:sup>\n                    microglia\/macrophages. Red-light treatment significantly reduced the cumulative mechanical sensitivity and the hypersensitivity incidence following SCI. This effect was accompanied by significantly reduced neuronal cell death, reduced astrocyte activation, and reduced iNOS expression in IBA1\n                    <jats:sup>+<\/jats:sup>\n                    cells at the level of the injury. However, myelin and NF200 immunoreactivity and IL-1\u03b2 expression in GFAP\n                    <jats:sup>+<\/jats:sup>\n                    and IBA1\n                    <jats:sup>+<\/jats:sup>\n                    cells were not altered by red-light treatment. Thus, red-light therapy may represent a useful non-pharmacological approach for treating pain during the subacute period after SCI by decreasing neuronal loss and modulating the inflammatory glial response.\n                  <\/jats:p>","DOI":"10.1089\/neu.2020.7066","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T01:47:51Z","timestamp":1592531271000},"page":"2244-2260","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Red-Light (670\u2009nm) Therapy Reduces Mechanical Sensitivity and Neuronal Cell Death, and Alters Glial Responses after Spinal Cord Injury in Rats"],"prefix":"10.1177","volume":"37","author":[{"given":"Di","family":"Hu","sequence":"first","affiliation":[{"name":"John Curtin School of Medical Research, Australian National University, Acton, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gila","family":"Moalem-Taylor","sequence":"additional","affiliation":[{"name":"Translational Neuroscience Facility, School of Medical Sciences, University of New South Wales, Sydney, Kensington, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason R.","family":"Potas","sequence":"additional","affiliation":[{"name":"John Curtin School of Medical Research, Australian National University, Acton, Australian Capital Territory, Australia."},{"name":"Translational Neuroscience Facility, School of Medical Sciences, University of New South Wales, Sydney, Kensington, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,15]]},"reference":[{"key":"e_1_3_4_2_2","article-title":"International perspectives on spinal cord injury","author":"World Health Organization and International Spinal Cord Society","year":"2013","unstructured":"World Health Organization and International Spinal Cord Society. 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