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In this article, we discuss types of neuroimaging not discussed in the guideline in terms of their safety for pediatric populations, their potential application, and the research investigating the future use of certain modalities to aid in the diagnosis and treatment of mTBI in children. The role of neuroimaging in pediatric mTBI cases should be considered for the potential contribution to children's neural and social development, in addition to the immediate clinical value (as in the case of acute structural findings). Selective use of specific neuroimaging modalities in research has already been shown to detect aspects of diffuse brain injury, disrupted cerebral blood flow, and correlate physiological factors with persistent symptoms, such as fatigue, cognitive decline, headache, and mood changes, following mTBI. However, these advanced neuroimaging modalities are currently limited to the research arena, and any future clinical application of advanced imaging modalities in pediatric mTBI will require robust evidence for each modality's ability to provide measurement of the subtle conditions of brain development, disease, damage, or degeneration, while accounting for variables at both non-injury and time-post-injury epochs. Continued collaboration and communication between researchers and healthcare providers is essential to investigate, develop, and validate the potential of advanced imaging modalities in pediatric mTBI diagnostics and management.<\/jats:p>","DOI":"10.1089\/neu.2020.7100","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T02:45:36Z","timestamp":1594262736000},"page":"44-52","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Neuroimaging in Pediatric Patients with Mild Traumatic Brain Injury: Relating the Current 2018 Centers for Disease Control Guideline and the Potential of Advanced Neuroimaging Modalities for Research and Clinical Biomarker Development"],"prefix":"10.1177","volume":"38","author":[{"given":"Alina K.","family":"Fong","sequence":"first","affiliation":[{"name":"CognitiveFx, Provo, Utah, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D.","family":"Allen","sequence":"additional","affiliation":[{"name":"CognitiveFx, Provo, Utah, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Waltzman","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC), National Center for Injury Prevention and Control (NCIPC), Division of Injury Prevention, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Sarmiento","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC), National Center for Injury Prevention and Control (NCIPC), Division of Injury Prevention, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith Owen","family":"Yeates","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Calgary, Calgary, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacy","family":"Suskauer","sequence":"additional","affiliation":[{"name":"Kennedy Krieger Institute, Baltimore, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Wintermark","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Stanford University, Stanford, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Lindberg","sequence":"additional","affiliation":[{"name":"Emergency Medicine, University of Colorado Denver, Denver, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F.","family":"Tate","sequence":"additional","affiliation":[{"name":"Missouri Institute of Mental Health, University of Missouri-St. Louis, St. Louis, Missouri, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Wilde","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaycie L.","family":"Loewen","sequence":"additional","affiliation":[{"name":"CognitiveFx, Provo, Utah, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.11.001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2010.05.017"},{"key":"e_1_3_3_4_2","volume-title":"Surveillance Report of Traumatic Brain Injury-related Emergency Department Visits, Hospitalizations, and Deaths\u2014United States, 2014","author":"Centers for Disease Control and Prevention","year":"2019","unstructured":"Centers for Disease Control and Prevention (2019). 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