{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:39:23Z","timestamp":1777927163602,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"20","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>\n                    The purpose of this study was to analyze brain natriuretic peptide (BNP) serum levels of patients with chronic subdural hematoma (cSDH) and their clinical implication. Patients with cSDH who underwent surgery in our department between November 2016 and October 2019 were eligible for enrollment in the study. Patients with recurrent bleedings, traumatic brain injury, cSDH associated with other intracranial pathologies, and those with a history of congestive heart failure, renal or endocrine disease were excluded. We measured BNP serum levels pre- and post-operatively and at discharge. The BNP values were analyzed with respect to patient medical history and neurological condition. The Glasgow Coma Scale score and the modified Rankin Scale score classified the clinical and neurological condition at the time of admission and discharge, respectively. The data of 100 surgically treated patients with cSDH (mean age 73.2, range 42\u2009\u2212\u200994 years, male\/female 3.5:1) were analyzed. Pre-operative BNP serum levels (BNP-1) were elevated in 67% of the patients (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200967; median\u2009=\u2009101.6\u2009pg\/mL;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). These serum levels increased after surgery (p\u2009&lt;\u20090.001) and decreased thereafter (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), reaching a level at discharge (day 7) that was not statistically different from BNP-1 (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&gt;\u20090.05). In addition, elevated BNP-1 showed a significant statistical association with the presence of atrial fibrillation (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and antiplatelet and\/or anticoagulant therapy (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.01). This study provides new evidence regarding BNP serum levels and their secretion pattern in patients with cSDH. Whether BNP-1 can predict the long-term functional outcome of patients with cSDH is being investigated in this ongoing prospective study.\n                  <\/jats:p>","DOI":"10.1089\/neu.2020.7110","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T06:56:38Z","timestamp":1591858598000},"page":"2211-2218","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Analysis of Brain Natriuretic Peptide Serum Levels in Patients with Symptomatic Chronic Subdural Hematoma: A Potential Reliable Biomarker"],"prefix":"10.1177","volume":"37","author":[{"given":"Mehdi","family":"Chihi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Gembruch","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvin","family":"Darkwah Oppong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz","family":"Helsper","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd-Otto","family":"H\u00fctter","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramazan","family":"Jabbarli","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten H.","family":"Wrede","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Sure","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homajoun","family":"Maslehaty","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2006.01.001"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/332078a0"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.09.024"},{"key":"e_1_3_4_5_2","first-page":"527","article-title":"Physiology of natriuretic peptides","volume":"235","author":"Espiner E.A.","year":"1994","unstructured":"Espiner E.A. (1994). Physiology of natriuretic peptides. Intern. Med. 235, 527\u2013541.","journal-title":"Intern. Med"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(92)90149-W"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1937-6448(10)80001-2"},{"issue":"18","key":"e_1_3_4_8_2","first-page":"891","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)","author":"Ponikowski P.","year":"2016","unstructured":"Ponikowski P., , Voors A.A., , Anker S.D., , Bueno H., , Cleland J.G., , Coats A.J., , Falk V., , Gonz\u00e1lez-Juanatey J.R., , Harjola V.P., , Jankowska E.A., , Jessup M., , Linde C., , Nihoyannopoulos P., , Parissis J.T., , Pieske B., , Riley J.P., , Rosano G.M., , Ruilope L.M., , Ruschitzka F., , Rutten F.H., , and van der Meer P. (2016). 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur. J. Heart Fail. 18, 891\u2013975.","journal-title":"Developed with the special contribution of the Heart Failure Association"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000083249"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.04.018"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.505354"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-005-0666-4"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.23.943"},{"key":"e_1_3_4_14_2","first-page":"820","article-title":"N-terminal pro-B-type natriuretic peptide in patients with isolated traumatic brain injury: a prospective cohort study","volume":"71","author":"Wu X.","year":"2011","unstructured":"Wu X., , Sha H., , Sun Y., , Gao L., , Liu H., , Yuan Q., , Zhang T., , Zhu J., , Zhou L., , and Hu J. (2011). N-terminal pro-B-type natriuretic peptide in patients with isolated traumatic brain injury: a prospective cohort study. J. Trauma, 71, 820\u2013825.","journal-title":"J. Trauma"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)08093-2"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000125016.37332.50"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1179\/016164104225017776"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000170699.59783.d6"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-018-1037-y"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885066616683677"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.3171\/2010.8.JNS10298"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/026990598121972"},{"key":"e_1_3_4_23_2","first-page":"401","article-title":"Assay and content of tissue thromboplastin in different organs","volume":"14","author":"Astrup T.","year":"1965","unstructured":"Astrup T. (1965). Assay and content of tissue thromboplastin in different organs. Thromb. Diath. Haemorrh. 14, 401\u2013416.","journal-title":"Thromb. Diath. Haemorrh"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0881-y"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx090"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.09.025"},{"key":"e_1_3_4_27_2","unstructured":"Galinier M. BNP. NT-proBNP: lequel choisir en pratique? R\u00e9alit\u00e9s cardiologiques. 2010. https:\/\/www.realites-cardiologiques.com\/wp-content\/uploads\/sites\/2\/2010\/11\/091.pdf (Last accessed June22 2020)."},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ensci.2019.100217"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.02.014"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0000000000000214"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/1099800417711584"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.3171\/2019.8.FOCUS19517"},{"key":"e_1_3_4_33_2","first-page":"1032","article-title":"Hemodynamic and oxygen transport patterns after head trauma and brain death: implications for management of the organ donor","volume":"63","author":"Belzberg H.","year":"2007","unstructured":"Belzberg H., , Shoemaker W.C., , Wo C.C., , Nicholls T.P., , Dang A.B., , Zelman V., , Gruen J.P., , Berne T.V., , and Demetriades D. (2007). Hemodynamic and oxygen transport patterns after head trauma and brain death: implications for management of the organ donor. J. Trauma, 63, 1032\u20131042.","journal-title":"J. Trauma"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.30.509"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.01.028"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01404"}],"container-title":["Journal of Neurotrauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/neu.2020.7110","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2020.7110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2020.7110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:36:39Z","timestamp":1777674999000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/neu.2020.7110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":35,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1089\/neu.2020.7110"],"URL":"https:\/\/doi.org\/10.1089\/neu.2020.7110","relation":{},"ISSN":["0897-7151","1557-9042"],"issn-type":[{"value":"0897-7151","type":"print"},{"value":"1557-9042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}