{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:25:11Z","timestamp":1783653911962,"version":"3.55.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"18","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2020,9]]},"abstract":"\n Pilot data of our phase IV clinical trial (pre\/post study design) highlighted a beneficial effect of intradetrusor onabotulinumtoxinA (200 IU) injections to reduce autonomic dysreflexia (AD) in individuals with chronic spinal cord injury (SCI) at T6 or above. After trial completion, we assessed whether our primary expectation (i.e., decrease of AD severity in 50% of participants during urodynamics [UDS]) was met. Secondary outcome measures were reduction of spontaneous AD in daily life as well as amelioration of AD-related and urinary incontinence-related quality of life (QoL). In addition, we conducted injury-level\u2013dependent analysis\u2014i.e., cervical and upper thoracic\u2014to explore group-specific treatment efficacy. Post-treatment, AD severity decreased in 82% (28\/34) of all participants during UDS and in 74% (25\/34) in daily life assessed with 24-h ambulatory blood pressure monitoring. In addition, urinary incontinence-related QoL was improved, cystometric capacity was increased, and maximum detrusor pressure during storage was reduced (all\n p<\/jats:italic>\n \u2009<\u20090.001). Further, the treatment was well tolerated, with only minor complications (grade I [\n n<\/jats:italic>\n \u2009=\u20097] and II [\n n<\/jats:italic>\n \u2009=\u20097]) in accordance with the Clavien-Dindo classification recorded in 11 individuals (cervical\n n<\/jats:italic>\n \u2009=\u20099, upper thoracic\n n<\/jats:italic>\n \u2009=\u20092). Injury-level\u2013dependent analysis revealed lower incidence (cervical\n n<\/jats:italic>\n \u2009=\u200915\/23, upper thoracic\n n<\/jats:italic>\n \u2009=\u20096\/11) and lesser severity (cervical\n p<\/jats:italic>\n \u2009=\u20090.009; upper thoracic\n p<\/jats:italic>\n \u2009=\u20090.06 [Pearson\n r<\/jats:italic>\n \u2009=\u2009\u22120.6, i.e., large effect size]) of AD during UDS. Further, reduced AD severity in daily life, improved urinary incontinence-related QoL, greater cystometric capacity, and lower maximum detrusor pressure during storage (all\n p<\/jats:italic>\n \u2009<\u20090.05) were found in both groups post-treatment. Intradetrusor onabotulinumtoxinA injections are an effective and safe second-line treatment option that ameliorates AD while improving lower urinary tract function and urinary incontinence-related QoL in individuals with cervical and upper thoracic SCI.\n <\/jats:p>","DOI":"10.1089\/neu.2020.7115","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T02:11:19Z","timestamp":1594087879000},"page":"2023-2027","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Intradetrusor OnabotulinumtoxinA Injections Ameliorate Autonomic Dysreflexia while Improving Lower Urinary Tract Function and Urinary Incontinence-Related Quality of Life in Individuals with Cervical and Upper Thoracic Spinal Cord Injury"],"prefix":"10.1177","volume":"37","author":[{"given":"Matthias","family":"Walter","sequence":"first","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Kran","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"MD Undergraduate Program, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Ramirez","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rapoport","sequence":"additional","affiliation":[{"name":"Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K.","family":"Nigro","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Stothers","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei V.","family":"Krassioukov","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"Division of Physical Medicine and Rehabilitation, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"G.F. Strong Rehabilitation Centre, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2004.21.1371"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1040-8"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1179\/2045772313Y.0000000098"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.5213\/inj.1836118.059"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4278"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1179\/204577211X13207446293695"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10066"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1179\/1079026812Z.00000000053"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu122"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)80384-7"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_3_5_13_2","first-page":"231","article-title":"Parametric measures of effect size, in: The Handbook of Research Synthesis","author":"Rosenthal R.","year":"1994","unstructured":"Rosenthal R. 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