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Typical complications include constipation, fecal impaction, incontinence, abdominal distention, autonomic dysreflexia, and the necessity of interventions (i.e., suppositories, digital stimulation) to defecate. Numerous surveys have confirmed that the remediation of bowel complications is more highly valued for quality of life than improvements in walking. Much of what is known about bowel function after SCI for diagnosis and research in humans has been gained using anorectal manometry (ARM) procedures. However, ARM has been underutilized in pre-clinical animal work. Therefore, a novel combination of outcome measures was examined in the current study that incorporates functional output of the bowel (weekly fecal measurements), weight gain (pre-injury to terminal weight), and terminal ARM measurement with external anal sphincter electromyography under urethane anesthesia. The results indicate higher fecal output after contusion during the sub-acute period (4\u20137 days) post-injury, changes in the composition of the feces, and functionally obstructive responses in a specific section of the rectum (increased baseline pressure, increased frequency of contraction, and reduced ability to trigger a giant contraction to a distension stimulus). These results demonstrate significant bowel dysfunction in the rodent SCI contusion model that is consistent with data from human research. Thus, the combined measurement protocol enables the detection of changes and can be used, with minimal cost, to assess effectiveness of therapeutic interventions on bowel complications.<\/jats:p>","DOI":"10.1089\/neu.2020.7145","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T07:16:51Z","timestamp":1591687011000},"page":"1971-1982","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Investigation of Bowel Function with Anorectal Manometry in a Rat Spinal Cord Contusion Model"],"prefix":"10.1177","volume":"37","author":[{"given":"Robert F.","family":"Hoey","sequence":"first","affiliation":[{"name":"Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles H.","family":"Hubscher","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, USA."},{"name":"Kentucky Spinal Cord Injury Research Center, Louisville, Kentucky, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2004.21.1371"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91487-7"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2002.11753617"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101058"},{"key":"e_1_3_4_6_2","first-page":"1114","article-title":"Chronic gastrointestinal problems in spinal cord injury patients: a prospective analysis","volume":"85","author":"Stone J.","year":"1990","unstructured":"Stone J., , Nino-Murcia M., , Wolfe V., , and Perkash I. 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