{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:39:43Z","timestamp":1777927183160,"version":"3.51.4"},"reference-count":63,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>\n                    One of the difficulties in identifying novel therapeutic strategies to manage central nervous system (CNS) trauma is the need for behavioral assays to assess chronic functional recovery.\n                    <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                    assays and\/or acute behavioral assessments cannot accurately predict long-term functional outcome. Using data from 13 independent T9 moderate contusive spinal cord injury (SCI) studies, we asked whether the ratio of acute (24\u201372\u2009h post-injury) changes in the levels of neuron-, oligodendrocyte-, astrocyte-specific and\/or endoplasmic reticulum stress response (ERSR) messenger ribonucleic acids (mRNAs) could predict the extent of chronic functional recovery. Increased levels of neuron, oligodendrocyte, and astrocyte mRNAs all correlated with enhanced Basso Mouse Scale (BMS) scores. Reduced levels of the ERSR mRNAs\n                    <jats:italic toggle=\"yes\">Atf4<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Chop<\/jats:italic>\n                    correlate with improved chronic locomotor function. Neither neural or ERSR mRNAs were predictive for chronic recovery across all behavioral changes. The ratio of oligodendrocyte\/ERSR mRNAs, however, did predict \u201cimproved,\u201d \u201cno change,\u201d or \u201cworse\u201d functional recovery. Neuronal\/ERSR mRNA ratios predicted functional improvement, but could not distinguish between worse or no change outcomes. Astrocyte\/ERSR mRNA ratios were not predictive. This approach can be used to confirm biological action of injected drugs\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    and to optimize dose and therapeutic window. It may prove useful in cervical and lumbar SCI and in other traumatic CNS injuries such as traumatic brain injury and stroke, where prevention of neuronal loss is paramount to functional recovery. Although the current analysis was directed toward ERSR whose activity was targeted in all but one study, acute mRNA markers for other pathophysiological cascades may be as predictive of chronic recovery when those cascades are targeted for neuroprotection.\n                  <\/jats:p>","DOI":"10.1089\/neu.2020.7258","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T03:27:23Z","timestamp":1603164443000},"page":"365-372","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Acute Neural and Proteostasis Messenger Ribonucleic Acid Levels Predict Chronic Locomotor Recovery after Contusive Spinal Cord Injury"],"prefix":"10.1177","volume":"38","author":[{"given":"Sujata","family":"Saraswat Ohri","sequence":"first","affiliation":[{"name":"Kentucky Spinal Cord Injury Research Center and Departments of University of Louisville School of Medicine, Louisville, Kentucky, USA."},{"name":"Neurological Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darlene A.","family":"Burke","sequence":"additional","affiliation":[{"name":"Kentucky Spinal Cord Injury Research Center and Departments of University of Louisville School of Medicine, Louisville, Kentucky, USA."},{"name":"Neurological Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kariena R.","family":"Andres","sequence":"additional","affiliation":[{"name":"Kentucky Spinal Cord Injury Research Center and Departments of University of Louisville School of Medicine, Louisville, Kentucky, USA."},{"name":"Neurological Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Hetman","sequence":"additional","affiliation":[{"name":"Kentucky Spinal Cord Injury Research Center and Departments of University of Louisville School of Medicine, Louisville, Kentucky, USA."},{"name":"Neurological Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA."},{"name":"Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, USA."},{"name":"Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott R.","family":"Whittemore","sequence":"additional","affiliation":[{"name":"Kentucky Spinal Cord Injury Research Center and Departments of University of Louisville School of Medicine, Louisville, Kentucky, USA."},{"name":"Neurological Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA."},{"name":"Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, USA."},{"name":"Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1995.12.1"},{"issue":"23","key":"e_1_3_3_3_2","first-page":"635","article-title":"Basso mouse scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains","author":"Basso D.M.","year":"2006","unstructured":"Basso D.M., , Fischer L.C., , Anderson A.J., , Jakeman L.B., , McTigue D.M., , and Popovich P.G. 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