{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:40:04Z","timestamp":1777927204932,"version":"3.51.4"},"reference-count":62,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>\n                    Mild traumatic brain injury (mTBI) is the most prevalent neurological insult and leads to long-lasting cognitive impairment. Neuroimaging studies have discovered abnormalities in brain network connectivity following mTBI as the underlying neural basis of cognitive deficits. However, the pathophysiologic mechanisms involved in imaging alterations remain elusive. Proteins neuron-specific enolase (NSE) and ubiquitin C terminal hydrolase 1 are reliable markers for neuronal cell-body damage, both of which have been demonstrated to be increased in serum following mTBI. Therefore, we conducted a longitudinal study to examine relationships between abnormal brain network connectivity and serum neuronal biomarkers and their associations with cognitive recovery following mTBI. Sixty patients were followed-up at 1 week and 3 months post-injury and 41 controls were recruited. Resting-state functional magnetic resonance imaging was used to build a functional connectivity matrix within large-scale intrinsic networks, and their topological properties were analyzed using graph theory measures. We found that, compared with controls, mTBI patients showed significant decreases in a number of nodal characteristics in default mode network (DMN), salience network, and executive network (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05, false discovery rate corrected) at 3 months post-injury. Linear regression analysis found elevated serum NSE in acute phase could predict lower efficiency and degree centrality of anterior DMN at 3 months post-injury. In addition, efficiency and degree centrality of anterior DMN were negatively associated with working memory. Our study showed neuronal injury was associated with alterations in brain network connectivity after mTBI. These findings can facilitate capability to predict the brain functional outcomes and cognitive recovery in mTBI.\n                  <\/jats:p>","DOI":"10.1089\/neu.2020.7372","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T10:34:17Z","timestamp":1615286057000},"page":"1495-1505","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Serum Neuron-Specific Enolase Levels Associated with Connectivity Alterations in Anterior Default Mode Network after Mild Traumatic Brain Injury"],"prefix":"10.1177","volume":"38","author":[{"given":"Yingxiang","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuoqiu","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China."},{"name":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghui","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Radiology, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefei","family":"Yang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Jia","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Bai","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70111-5"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70262-4"},{"key":"e_1_3_4_4_2","first-page":"789","article-title":"Outcome in 1,000 head injury hospital admissions: the Athens head trauma registry","volume":"65","author":"Stranjalis G.","year":"2008","unstructured":"Stranjalis G., , Bouras T., , Korfias S., , Andrianakis I., , Pitaridis M., , Tsamandouraki K., , Alamanos Y., , Sakas D.E., , and Marmarou A. 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