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Brain-derived neurotrophic factor (BDNF) and activation of its receptor tropomycin-related kinase B (TrkB) have neuroprotective effects in a number of degeneration models. Small molecule activators of TrkB, such as N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide (HIOC), cross the blood\u2013brain and blood-retina barriers after systemic administration. We characterize the effects of blast-induced ocular trauma on retinal and visual function. We show that systemic administration of HIOC, a potent small molecule activator of the BDNF\/TrkB receptor, preserves visual function in mice exposed to ocular blast injury. The HIOC treatment for one week preserves visual function for at least four months. The HIOC treatment effectively protected vision when the initial dose was administered up to 3\u2009h after blast, but not if the initial treatment was delayed for 24\u2009h. We provide evidence that the therapeutic effect of HIOC is mediated by activation of BDNF\/TrkB receptors. The results indicate that HIOC may be useful for managing ocular blast injury and other forms of traumatic optic neuropathy.<\/jats:p>","DOI":"10.1089\/neu.2020.7392","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T04:40:23Z","timestamp":1628224823000},"page":"2896-2906","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["A Tropomycin-Related Kinase B Receptor Activator for the Management of Ocular Blast-Induced Vision Loss"],"prefix":"10.1177","volume":"38","author":[{"given":"Susov","family":"Dhakal","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Emory University, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"He","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polina","family":"Lyuboslavsky","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curran","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micah A.","family":"Chrenek","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana T.","family":"Sellers","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey H.","family":"Boatright","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eldon E.","family":"Geisert","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah A.","family":"Setterholm","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Emory University, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank E.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Emory University, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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