{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:51:43Z","timestamp":1788317503949,"version":"build-2803163510"},"reference-count":27,"publisher":"SAGE Publications","issue":"19","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>\n                    The benefits of therapeutic hypothermia (TH) in severe traumatic brain injury (sTBI) have been long debated. In 2018, the POLAR study, a high-quality international trial, appeared to end the debate by showing that TH did not improve mortality in sTBI. However, the POLAR-based recommendation to abandon TH was challenged by different investigators. In our recent meta-analysis, we introduced the cooling index (COIN) to assess the extent of cooling and showed that TH is beneficial in sTBI, but only when the COIN is sufficiently high. In the present study, we calculated the COIN for the POLAR study and ran a new meta-analysis, which included the POLAR data and accounted for the cooling extent. The POLAR study targeted a high cooling extent (COIN of 276\u00b0C\u2009\u00d7\u2009h; calculated for 72\u2009h), but the achieved cooling was much lower (COIN of 193\u00b0C\u2009\u00d7\u2009h)\u2014because of deviations from the protocol. When the POLAR data were included in the COIN-based meta-analysis, TH had an overall effect of reducing death (odds rate of 0.686;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.007). Among the subgroups with different COIN levels, the only significantly decreased odds rate (i.e., beneficial effect of TH) was observed in the subgroup with high COIN (0.470;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.013). We conclude that, because of deviations from the targeted cooling protocol, the overall cooling extent was not sufficiently high in the POLAR study, thus masking the beneficial effects of TH. The current analysis shows that TH is beneficial in sTBI, but only when the COIN is high. Abandoning the use of TH in sTBI may be premature.\n                  <\/jats:p>","DOI":"10.1089\/neu.2020.7509","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T05:26:07Z","timestamp":1621315567000},"page":"2772-2776","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["POLAR Study Revisited: Therapeutic Hypothermia in Severe Brain Trauma Should Not Be Abandoned"],"prefix":"10.1177","volume":"38","author":[{"given":"Emoke","family":"Olah","sequence":"first","affiliation":[{"name":"Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Poto","sequence":"additional","affiliation":[{"name":"Institute of Bioanalysis, Medical School, University of Pecs, Pecs, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Rumbus","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Pakai","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej A.","family":"Romanovsky","sequence":"additional","affiliation":[{"name":"School of Molecular Sciences, University of Arizona, Tempe, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hegyi","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Garami","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.17075"},{"key":"e_1_3_4_3_2","first-page":"95","article-title":"Therapeutic hypothermia after traumatic brain injury: wrong hypotheses may lead to specious interpretations","volume":"38","author":"Bouzat P.","year":"2019","unstructured":"Bouzat P., , and Payen J.F. 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