{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:40:26Z","timestamp":1777927226847,"version":"3.51.4"},"reference-count":73,"publisher":"SAGE Publications","issue":"1-2","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Traumatic brain injury (TBI) represents a critical public health problem around the world. To date, there are no accurate therapeutic approaches for the management of cardiovascular impairments induce by TBI. In this regard, hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S), a novel gasotransmitter, has been proposed as a neuro- and cardioprotective molecule. This study was designed to determine the effect of subchronic management with sodium hydrosulfide (NaHS) on hemodynamic, vasopressor sympathetic outflow and sensorimotor alterations produced by TBI. Animals underwent a lateral fluid percussion injury, and changes in hemodynamic variables were measured by pletismographic methods. In addition, vasopressor sympathetic outflow was assessed by a pithed rat model. Last, sensorimotor impairments were evaluated by neuroscore test and beam-walking test. At seven, 14, 21, and 28 days after moderate-severe TBI, the animals showed: (1) a decrease on sensorimotor function in the neuroscore test and beam-walking test; (2) an increase in heart rate, systolic, diastolic, and mean blood pressure; (3) progressive sympathetic hyperactivity; and (4) a decrease in vasopressor responses induced by noradrenaline (\u03b1\n                    <jats:sub>1\/2<\/jats:sub>\n                    -adrenoceptors agonist) and UK 14,304 (selective \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    -adrenoceptor agonist). Interestingly, intraperitoneal daily injections of NaHS, an H\n                    <jats:sub>2<\/jats:sub>\n                    S donor (3.1 and 5.6\u2009mg\/kg), during seven days after TBI prevented the development of the impairments in hemodynamic variables, which were similar to those obtained in sham animals. Moreover, NaHS treatment prevented the sympathetic hyperactivity and decreased noradrenaline-induced vasopressor responses. No effects on sensorimotor dysfunction were observed, however. Taken together, our results suggest that H\n                    <jats:sub>2<\/jats:sub>\n                    S ameliorates the hemodynamic and sympathetic system impairments observed after TBI.\n                  <\/jats:p>","DOI":"10.1089\/neu.2020.7552","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T04:40:17Z","timestamp":1614228017000},"page":"181-195","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Hydrogen Sulfide Subchronic Treatment Improves Hypertension Induced by Traumatic Brain Injury in Rats through Vasopressor Sympathetic Outflow Inhibition"],"prefix":"10.1177","volume":"39","author":[{"given":"Sa\u00fal","family":"Huerta de la Cruz","sequence":"first","affiliation":[{"name":"Departamento de Farmacobiolog\u00eda, Cinvestav-Coapa, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Rocha","sequence":"additional","affiliation":[{"name":"Departamento de Farmacobiolog\u00eda, Cinvestav-Coapa, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Santiago-Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Departamento de Farmacobiolog\u00eda, Cinvestav-Coapa, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Araceli","family":"S\u00e1nchez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacobiolog\u00eda, Cinvestav-Coapa, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alma D.","family":"Pinedo-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacobiolog\u00eda, Cinvestav-Coapa, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grecia J.","family":"Medina-Terol","sequence":"additional","affiliation":[{"name":"Departamento de Farmacobiolog\u00eda, Cinvestav-Coapa, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Centuri\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Farmacobiolog\u00eda, Cinvestav-Coapa, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30415-0"},{"key":"e_1_3_6_3_2","first-page":"1","article-title":"Traumatic Brain Injury in the United States: Epidemiology and Rehabilitation","author":"Frieden T.R.","year":"2015","unstructured":"Frieden T.R., , Houry D., , and Baldwin G. 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