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The chinchillas were exposed to single unilateral blast-overpressure (BOP) at \u223c172dB peak sound pressure level (SPL) and the pathological changes were compared at 1 week and 1 month after BOP. The functional integrity of the auditory system was assessed by auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE). The axonal integrity was assessed using diffusion tensor imaging at regions of interests (ROIs) of the central auditory neuraxis (CAN) including the cochlear nucleus (CN), inferior colliculus (IC), and auditory cortex (AC). Post-BOP, cyto-architecture metrics such as viable cells, degenerating neurons, and apoptotic cells were quantified at the CAN ROIs using light microscopic studies using cresyl fast violet, hematoxylin and eosin, and modified Crossmon's trichrome stains. We observed mean ABR threshold shifts of 30- and 10-dB SPL at 1 week and 1 month after BOP, respectively. A similar pattern was observed in DPAOE amplitudes shift. In the CAN ROIs, diffusion tensor imaging studies showed a decreased axial diffusivity in CN 1 month after BOP and a decreased mean diffusivity and radial diffusivity at 1 week after BOP. However, morphometric measures such as decreased viable cells and increased degenerating neurons and apoptotic cells were observed at CN, IC, and AC. Specifically, increased degenerating neurons and reduced viable cells were high on the ipsilateral side when compared with the contralateral side. These results indicate that a single blast significantly damages structural and functional integrity at all levels of CAN ROIs.<\/jats:p>","DOI":"10.1089\/neu.2020.7556","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T11:47:32Z","timestamp":1633348052000},"page":"3248-3259","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Correlation of Histomorphometric Changes with Diffusion Tensor Imaging for Evaluation of Blast-Induced Auditory Neurodegeneration in Chinchilla"],"prefix":"10.1177","volume":"38","author":[{"given":"Kathiravan","family":"Kaliyappan","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences, School of Public Health and Health Professions, College of Arts and Sciences, University at Buffalo, Buffalo, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Nakuci","sequence":"additional","affiliation":[{"name":"Neuroscience Program, College of Arts and Sciences, University at Buffalo, Buffalo, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilena","family":"Preda","sequence":"additional","affiliation":[{"name":"Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, College of Arts and Sciences, University at Buffalo, Buffalo, New York, USA."},{"name":"Center for Biomedical Imaging, Clinical and Translational Science Institute, College of Arts and Sciences, University at Buffalo, Buffalo, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"Schweser","sequence":"additional","affiliation":[{"name":"Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, College of Arts and Sciences, University at Buffalo, Buffalo, New York, USA."},{"name":"Center for Biomedical Imaging, Clinical and Translational Science Institute, College of Arts and Sciences, University at Buffalo, Buffalo, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Muldoon","sequence":"additional","affiliation":[{"name":"Department of Mathematics, College of Arts and Sciences, University at Buffalo, Buffalo, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya Prakash","family":"Krishnan Muthaiah","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, School of Public Health and Health Professions, College of Arts and Sciences, University at Buffalo, Buffalo, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5220"},{"key":"e_1_3_5_3_2","first-page":"1257","article-title":"Neurological effects of blast injury","volume":"68","author":"Hicks R.R.","year":"2010","unstructured":"Hicks R.R., , Fertig S.J., , Desrocher R.E., , Koroshetz W.J., , and Pancrazio J.J. 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