{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:40:30Z","timestamp":1777927230472,"version":"3.51.4"},"reference-count":61,"publisher":"SAGE Publications","issue":"15","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>\n                    Complete spinal cord lesions interrupt the connection of all axonal projections with their neuronal targets below and above the lesion site. In particular, the interruption of connections with the neurons at lumbar segments after thoracic injuries impairs voluntary body control below the injury. The failure of spontaneous regrowth of transected axons across the lesion prevents the reconnection and reinnervation of the neuronal targets. At present, the only treatment in humans that has proven to promote some degree of locomotor recovery is physical therapy. The success of these strategies, however, depends greatly on the type of lesion and the level of preservation of neural tissue in the spinal cord after injury. That is the reason it is key to design strategies to promote axonal regrowth and neuronal reconnection. Here, we test the use of a developmental axon guidance molecule as a biological agent to promote axonal regrowth, axonal reconnection, and recovery of locomotor activity after spinal cord injury (SCI). This molecule, netrin-1, guides the growth of the\n                    <jats:underline>c<\/jats:underline>\n                    ortico\n                    <jats:underline>s<\/jats:underline>\n                    pinal\n                    <jats:underline>t<\/jats:underline>\n                    ract (CST) during the development of the central nervous system. To assess the potential of this molecule, we used a model of complete spinal cord transection in rats, at thoracic level 10\u201311. We show that\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    delivery of netrin-1 at the epicenter of the lesion: (1) promotes regrowth of CST through the lesion and prevents CST dieback, (2) promotes synaptic reconnection of regenerated motor and sensory axons, and (3) preserves the polymerization of the neurofilaments in the sciatic nerve axons. These anatomical findings correlate with a significant recovery of locomotor function. Our work identifies netrin-1 as a biological agent with the capacity to promote the functional repair and recovery of locomotor function after SCI. These findings support the use of netrin-1 as a therapeutic intervention to be tested in humans.\n                  <\/jats:p>","DOI":"10.1089\/neu.2020.7571","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T06:18:43Z","timestamp":1613629123000},"page":"2084-2102","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Intraspinal Administration of Netrin-1 Promotes Locomotor Recovery after Complete Spinal Cord Transection"],"prefix":"10.1177","volume":"38","author":[{"given":"H\u00e9ctor R.","family":"Quint\u00e1","sequence":"first","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas\u2013CONICET, Buenos Aires, Argentina."},{"name":"Laboratorio de Medicina Experimental \u201cDr. Jorge E. Toblli,\u201d Hospital Alem\u00e1n. CABA, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2008.06.0074"},{"key":"e_1_3_6_3_2","first-page":"15","article-title":"Pharmacological interventions for spinal cord injury: where do we stand?","volume":"132","author":"Rabchevsky A.G.","year":"2011","unstructured":"Rabchevsky A.G., , Patel S.P., , and Springer J.E. (2011). Pharmacological interventions for spinal cord injury: where do we stand?. How might we step forward? Pharmacol. Ther. 132, 15\u201329.","journal-title":"How might we step forward? Pharmacol. 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