{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:25:10Z","timestamp":1791066310607,"version":"4.1.0"},"reference-count":63,"publisher":"SAGE Publications","issue":"19","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>\n                    The purpose of this study is to assess the relationship between regional white matter diffusion imaging changes and finite element strain measures in nonconcussed youth football players. Pre- and post-season diffusion-weighted imaging was performed in 102 youth football subject-seasons, in which no concussions were diagnosed. The diffusion data were normalized to the IXI template. Percent change in fractional anisotropy (%\u0394FA) images were generated. Using data from the head impact telemetry system, the cumulative maximum principal strain one times strain rate (CMPS1\n                    <jats:bold>\u2009\u00d7<\/jats:bold>\n                    \u2009SR), a measure of the cumulative tensile brain strain and strain rate for one season, was calculated for each subject. Two linear regression analyses were performed to identify significant positive or inverse relationships between CMPS1\n                    <jats:bold>\u2009\u00d7<\/jats:bold>\n                    \u2009SR and %\u0394FA within the international consortium for brain mapping white matter mask. Age, body mass index, days between pre- and post-season imaging, previous brain injury, attention disorder diagnosis, and imaging protocol were included as covariates. False discovery rate correction was used with corrected alphas of 0.025 and voxel thresholds of zero. Controlling for all covariates, a significant, positive linear relationship between %\u0394FA and CMPS1\n                    <jats:bold>\u2009\u00d7<\/jats:bold>\n                    \u2009SR was identified in the bilateral cingulum, fornix, internal capsule, external capsule, corpus callosum, corona radiata, corticospinal tract, cerebral and middle cerebellar peduncle, superior longitudinal fasciculus, and right superior fronto-occipital fasciculus.\n                    <jats:italic toggle=\"yes\">Post hoc<\/jats:italic>\n                    analyses further demonstrated significant %\u0394FA differences between high-strain football subjects and noncollision control athletes, no significant %\u0394FA differences between low-strain subjects and noncollision control athletes, and that CMPS1\n                    <jats:bold>\u2009\u00d7<\/jats:bold>\n                    \u2009SR significantly explained more %\u0394FA variance than number of head impacts alone.\n                  <\/jats:p>","DOI":"10.1089\/neu.2020.7580","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T03:30:05Z","timestamp":1622086205000},"page":"2763-2771","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Regional White Matter Diffusion Changes Associated with the Cumulative Tensile Strain and Strain Rate in Nonconcussed Youth Football Players"],"prefix":"10.1177","volume":"38","author":[{"given":"James M.","family":"Holcomb","sequence":"first","affiliation":[{"name":"University of Texas Southwestern Medical Center, Dallas, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan A.","family":"Fisicaro","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Dallas, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan E.","family":"Miller","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine, Winston-Salem, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang F.","family":"Yu","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Dallas, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Davenport","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Dallas, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Xi","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Dallas, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian E.","family":"Urban","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine, Winston-Salem, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben C.","family":"Wagner","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Dallas, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander K.","family":"Powers","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine, Winston-Salem, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Whitlow","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine, Winston-Salem, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D.","family":"Stitzel","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine, Winston-Salem, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Maldjian","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Dallas, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001199-200609000-00001"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.06.003"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.01.013"},{"key":"e_1_3_5_5_2","first-page":"45","volume-title":"Handbook of Clinical Neurology","author":"McKee A.C.","year":"2015","unstructured":"McKee A.C., and Daneshvar D.H. 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