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This work aimed at characterizing a model of cervical SCI in domestic pigs in which hemisection with excision of 1\u2009cm of spinal cord was performed to reproduce the loss of neural tissue observed in human neuropathology. Posture and motor control were assessed over 3 months by scales and kinematics of treadmill locomotion. Histological measurements included lesion length, atrophy of the adjacent spinal cord segments, and neuronal death. In some animals, the retrograde neural tracer aminostilbamidine was injected in segments caudal to the lesion to visualize propriospinal projection neurons. Neuronal loss extended for 4\u20136\u2009mm from the lesion borders and was more severe in the ipsilateral, caudal spinal cord stump. Axonal Wallerian degeneration was observed caudally and rostrally, associated with marked atrophy of the white matter in the spinal cord segments adjacent to the lesion. The pigs showed chronic monoplegia or severe monoparesis of the foreleg ipsilateral to the lesion, whereas the trunk and the other legs had postural and motor impairments that substantially improved during the first month post-lesion. Adaptations of the walking cycle such as those reported for rats and humans ameliorated the negative impact of focal neurological deficits on locomotor performance. These results provide a baseline of behavior and histology in a porcine model of cervical spinal cord hemisection that can be used for translational research in SCI therapeutics.<\/jats:p>","DOI":"10.1089\/neu.2020.7587","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T02:42:25Z","timestamp":1623638545000},"page":"2956-2977","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Neuropathological and Motor Impairments after Incomplete Cervical Spinal Cord Injury in Pigs"],"prefix":"10.1177","volume":"38","author":[{"given":"Patricia Del","family":"Cerro","sequence":"first","affiliation":[{"name":"Neural Repair Laboratory, Hospital Nacional de Parapl\u00e9jicos, Toledo, Spain."},{"name":"Program in Neuroscience, Autonoma de Madrid University, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Barriga-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery and Traumatology, Hospital Nacional de Parapl\u00e9jicos, Toledo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Vara","sequence":"additional","affiliation":[{"name":"Neural Repair Laboratory, Hospital Nacional de Parapl\u00e9jicos, Toledo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M.","family":"Romero-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery and Traumatology, Hospital Nacional de Parapl\u00e9jicos, Toledo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Rodr\u00edguez-De-Lope","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital Virgen de la Salud, Toledo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E.","family":"Collazos-Castro","sequence":"additional","affiliation":[{"name":"Neural Repair Laboratory, Hospital Nacional de Parapl\u00e9jicos, Toledo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,10,14]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"National Spinal Cord Injury Statistical Center (2020). 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