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Cognitive deficits suggest dysfunction in hippocampal circuits. The goal of the studies described here is to phenotype in both male and female mice the hippocampal-dependent learning and memory deficits resulting from TBI sustained by the Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA) device\u2014a model that delivers both a contact\u2013concussion injury as well as unrestrained rotational head movement. Mice sustained either sham procedures or four injuries (0.7\u2009J, 24-h intervals). Spatial learning and memory skills assessed in the Morris water maze (MWM) approximately 3 weeks following injuries were significantly impaired by brain injuries; however, slower swimming speeds and poor performance on visible platform trials suggest that measurement of cognitive impairment with this test is confounded by injury-induced motor and\/or visual impairments. A separate experiment confirmed hippocampal-dependent cognitive deficits with trace fear conditioning (TFC), a behavioral test less dependent on motor and visual function. Male mice had greater injury-induced deficits on both the MWM and TFC tests than female mice. Pathologically, the injury was characterized by white matter damage as observed by silver staining and glial fibrillary acidic protein (astrogliosis) in the optic tracts, with milder damage seen in the corpus callosum, and fimbria and brainstem (cerebral peduncles) of some animals. No changes in the density of GABAergic parvalbumin-expressing cells in the hippocampus, amygdala, or parietal cortex were found. This experiment confirmed significant sexually dimorphic cognitive impairments following a repeated, diffuse brain injury.<\/jats:p>","DOI":"10.1089\/neu.2021.0025","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T03:05:08Z","timestamp":1614135908000},"page":"1585-1606","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Hippocampal-Dependent Cognitive Dysfunction following Repeated Diffuse Rotational Brain Injury in Male and Female Mice"],"prefix":"10.1177","volume":"38","author":[{"given":"Laura B.","family":"Tucker","sequence":"first","affiliation":[{"name":"Center for Neuroscience and Regenerative Medicine, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."},{"name":"Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda H.","family":"Fu","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Regenerative Medicine, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."},{"name":"Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph T.","family":"McCabe","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Regenerative Medicine, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."},{"name":"Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30415-0"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-2007-22502"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1313"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.2997"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1018"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2017-097791"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.4085\/1062-6050-52.1.14"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.8334"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12248"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22690"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws322"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0819-18.2018"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.02.017"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-9-55"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5348"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31821f891f"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.03.010"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-017-0762-x"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180871"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep41269"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.08.030"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2009.10.022"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.3019"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3816-2_1"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3816-2_3"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3407"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1454-5"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1988.5.1"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1987.67.1.0110"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1945.25.2.296"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1973.39.2.0152"},{"issue":"7","key":"e_1_3_6_33_2","first-page":"23","article-title":"Acceleration induced head injury in the monkey","author":"Gennarelli T.A.","year":"1981","unstructured":"Gennarelli T.A., , Adams J.H., , and Graham D.I. 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