{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:40:40Z","timestamp":1777927240853,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"17","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>\n                    The main objective of this prospective cohort study was to evaluate whether traumatic microbleeds (TMBs) are a significant prognostic factor of return to work (RTW), post-traumatic symptoms, and overall recovery in patients with mild traumatic brain injury (mTBI). One hundred and thirteen patients with mTBI were recruited from the Helsinki University Hospital emergency units. All patients underwent multi-contrast 3T magnetic resonance imaging (MRI) 3\u201317 days after mTBI. Patients were evaluated in the Traumatic Brain Injury Outpatient Clinic of Helsinki University Hospital 1 month after injury. Post-concussion symptoms were assessed with the Post-Concussion Symptom Questionnaire (RPQ) and overall recovery was assessed with the Glasgow Outcome Scale Extended (GOS-E). Their time to RTW was continuously measured up to 1 year after TBI. Median RTW was 9 days (interquartile range [IQR] 4\u201330) after mTBI and full RTW rate after 1 year was 98%. Patients with TMBs (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200922) did not have more post-concussion symptoms (median RPQ 10.0 vs. 7.0,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.217) or worse overall recovery (58% vs. 56% with GOS-E\u2009=\u20098,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.853) than patients without TMBs (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200991). There was no significant difference in time to RTW (13.5 vs. 7.0 days,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.063). In this study, patients with TMBs did not have delayed RTW or more post-concussion symptoms than other patients with mTBI. TMBs in mTBI do not seem to be a significant prognostic factor of RTW.\n                  <\/jats:p>","DOI":"10.1089\/neu.2021.0055","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T08:36:56Z","timestamp":1618303016000},"page":"2400-2406","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Traumatic Microbleeds in Mild Traumatic Brain Injury Are Not Associated with Delayed Return to Work or Persisting Post-Concussion Symptoms"],"prefix":"10.1177","volume":"38","author":[{"given":"Antti","family":"Huovinen","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Marinkovic","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harri","family":"Isokuortti","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"Korvenoja","sequence":"additional","affiliation":[{"name":"Department of HUS Medical Imaging Center, Radiology, and Departments of University of Helsinki and Helsinki University Hospital, Helsinki, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaisa","family":"M\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology and University of Helsinki and Helsinki University Hospital, Helsinki, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taina","family":"Nybo","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology and University of Helsinki and Helsinki University Hospital, Helsinki, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Melkas","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz290"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00178"},{"key":"e_1_3_5_4_2","author":"Moe H.K.","year":"2019","unstructured":"Moe H.K., , Limandvik Myhr J., , Moen K.G., , H\u00e5berg A.K., , Skandsen T., , and Vik A. 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Post-concussion symptoms in complicated vs. uncomplicated mild traumatic brain injury patients at three and six months post-injury: results from the CENTER-TBI Study. J. Clin. Med. 8, 1921.","journal-title":"J. Clin. Med"},{"key":"e_1_3_5_18_2","author":"Carroll L.J.","unstructured":"Carroll L.J., , Cassidy J.D., , Holm L., , Kraus J., , Coronado V.G., and WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury (2004). Methodological issues and research recommendations for mild traumatic brain injury: the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. J. Rehabil. Med. (43 Suppl), 113\u2013125.","journal-title":"J. Rehabil. 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